Trial reportFrontiers in medicine2026
Oliceridine effectively attenuates fentanyl-induced cough during general anesthesia induction.
Trial report in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of tegileridine pretreatment on fentanyl-induced cough during general anesthesia induction: a randomized controlled trial.Frontiers in medicine · 2026Trial
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Fentanyl-induced cough (FIC) is a common adverse event during anesthesia induction with a high incidence and may result in serious clinical complications. Although our clinical observations suggest that oliceridine attenuates FIC, the available evidence remains limited. This study was designed to assess the prophylactic efficacy of oliceridine against FIC and to characterize its peri-induction safety profile. Methods: A total of 168 adult surgical patients with American Society of Anesthesiologists physical status I-III scheduled for general anesthesia were randomized to receive either oliceridine 2 mg (OF group) or normal saline (SF group) prior to fentanyl administration. The primary outcome was the incidence of cough within 1 min following fentanyl injection. Secondary outcomes included cough severity, vital sign changes, and the incidence of adverse events. Results: No patients in the OF group experienced FIC, compared to 58.33% in the SF group ( Conclusion: Pretreatment with 2 mg oliceridine effectively reduces the incidence of FIC without increasing significant additional risks, providing a rationale and safe approach for anesthetic induction. Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=272947, identifier ChiCTR2500105221.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.