Evidence map›Paper›PMID 42221004›Full record

ArticleFrontiers in pediatrics2026

Maintenance oral viscous budesonide reduces dilation recurrence after esophageal atresia repair: a prospective clinical study.

Cosimo Ruggiero, Giusy Russo, Denis Cozzi, Danila Volpe, Silvia Ceccanti, Paola Papoff, Miriam D'Orsi, Tonia Raso, Giulia Mancuso, Salvatore Oliva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cosimo RuggieroPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.
Giusy RussoPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.
Denis CozziPediatric Surgery Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.
Danila VolpePediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.
Silvia CeccantiPediatric Surgery Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.
Paola PapoffPediatric Intensive Care Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.
Miriam D'OrsiPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.
Tonia RasoPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.
Giulia MancusoPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.
Salvatore OlivaPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recurrent anastomotic stricture (AS) remains a major cause of morbidity after esophageal atresia (EA) repair. Although oral viscous budesonide (OVB) reduces dilation requirements during active treatment, the durability of this benefit after treatment discontinuation remains unclear. Methods: We conducted a prospective, open-label, randomized study including children with repaired EA and steroid-responsive recurrent AS. Patients were randomized (1:1) to continue OVB maintenance therapy or discontinue treatment. The primary outcome was dilation-free survival. Secondary outcomes included dysphagia severity, radiologic stricture severity, and safety. Results: Twenty-two patients were included in the final analysis (OVB Conclusions: Maintenance OVB significantly prolongs dilation-free intervals in children with recurrent AS after EA repair, supporting topical anti-inflammatory therapy as a potential disease-modifying strategy.

Indexed as

anastomotic stricturedilationdiscontinuation effectsesophageal atresiamaintenance treatmentoral viscous budesonide

Identifiers

PMID42221004
PMCPMC13216221

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.