Evidence map›Paper›PMID 42221001›Full record

ReviewFrontiers in pediatrics2026

Age-stratified management of pediatric perianal abscesses: a proposed framework integrating the "Developmental Healing Axis".

He-Xue Yuan, Zhi-Tao Yin, Li-Hua Wang, Lin Ma, Yang Liu, Yu-Lin Ju, Bin Yue

Abstract readReview
In one paragraph

Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

He-Xue Yuan *Department of Anorectal Surgery, Shenyang Coloproctology Hospital, Shenyang, Liaoning, China.
Zhi-Tao Yin *Department of Anorectal Surgery, Shenyang Coloproctology Hospital, Shenyang, Liaoning, China.
Li-Hua WangDepartment of Anorectal Surgery, Shenyang Coloproctology Hospital, Shenyang, Liaoning, China.
Lin MaDepartment of Anorectal Surgery, Shenyang Coloproctology Hospital, Shenyang, Liaoning, China.
Yang LiuDepartment of Anorectal Surgery, Shenyang Coloproctology Hospital, Shenyang, Liaoning, China.
Yu-Lin JuDepartment of Anorectal Surgery, Shenyang Coloproctology Hospital, Shenyang, Liaoning, China.
Bin YueDepartment of Anorectal Surgery, Shenyang Coloproctology Hospital, Shenyang, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric perianal abscesses represent a frequent yet underrecognized condition that poses diagnostic and therapeutic challenges due to tissue fragility and age-dependent healing dynamics. This review synthesizes current evidence on the epidemiology, pathophysiology, and management of pediatric perianal abscesses to provide a conceptual basis for clinical decision-making. Surgical interventions such as incision and drainage offer rapid symptom relief but may increase the risk of fistula formation, particularly in older children. In contrast, conservative strategies including antibiotic therapy and observation are often effective in infants and young children, reflecting their superior regenerative capacity. Age-related differences in immune response, microbiota composition, and glandular anatomy contribute to variations in disease progression and healing outcomes. By integrating data from recent studies and clinical guidelines, this review highlights the importance of individualized, age-specific management to optimize recovery, minimize recurrence, and prevent fistula development. Furthermore, it identifies gaps in current evidence and underscores the need for standardized treatment protocols and future research into predictive and microbiome-related factors influencing disease course.

Indexed as

age-specific managementfistula-in-anoincision and drainage (I&D)minimally invasive surgerynon-cutting setonpediatric perianal abscessspontaneous resolution

Identifiers

PMID42221001
PMCPMC13219376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.