ArticleInternational journal of nanomedicine2026
Thermosensitive in situ Hydrogel Based on Benzalkonium Chloride-Loaded Selenium-Doped Mesoporous Silica Nanoparticles for Diabetic Chronic Wound Treatment.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetic chronic wounds are characterized by persistent infection, excessive oxidative stress, impaired angiogenesis, and prolonged inflammation, resulting in delayed healing. Current wound dressings lack the ability to simultaneously regulate these pathological processes. Methods: A multifunctional composite hydrogel was developed by incorporating benzalkonium chloride (BAC)-loaded selenium-doped mesoporous silica nanoparticles (Se-MSNs) into a PF127 matrix. In this system, BAC provides antibacterial activity, Se-MSNs enable redox regulation and immunomodulation, and PF127 serves as a delivery platform for localized retention and sustained release. The physicochemical properties, antibacterial activity, antioxidant capacity, pro-angiogenic effects, and anti-inflammatory performance were evaluated in vitro, followed by therapeutic assessment in a diabetic mouse wound model. Results: The composite hydrogel exhibited effective antibacterial activity against Staphylococcus aureus and Escherichia coli, reduced intracellular reactive oxygen species, promoted endothelial cell migration and tube formation, and modulated inflammatory cytokine expression in vitro. In vivo, the hydrogel significantly accelerated wound closure, enhanced collagen deposition and angiogenesis, and alleviated excessive inflammation in diabetic wounds. Conclusion: The therapeutic effects of the composite hydrogel are attributed to the restoration of redox homeostasis and the coordinated regulation of inflammation resolution and vascular regeneration. This study presents a multifunctional biomaterial strategy for improving the healing of diabetic chronic wounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.