Evidence map›Paper›PMID 42220965›Full record

ArticleWorld journal of clinical pediatrics2026

Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients.

Eman Ahmed Abd-Elmawgood, Mohammed H Hassan, Khaled Abdalla Abd-Elbaseer, Mona Hashem Ibrahem, Khaled Mohammed Hassan Yousef, Ali Helmi Bakri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eman Ahmed Abd-ElmawgoodDepartment of Pediatrics, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Mohammed H HassanDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Khaled Abdalla Abd-ElbaseerDepartment of Pediatrics, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Mona Hashem IbrahemDepartment of Pediatrics, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Khaled Mohammed Hassan YousefDepartment of Biochemistry, Faculty of Pharmacy, Qena University, Qena 83523, Egypt.
Ali Helmi BakriDepartment of Pediatrics, Faculty of Medicine, Qena University, Qena 83523, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowth differentiation factor-15 (GDF-15) is a stress-responsive cytokine. Though less extensively studied in children than in adults, recent evidence highlights the potential value of GDF-15 in pediatric cardiology.

aimTo assess the serum GDF-15 levels and the genetic profile of GDF-15 rs4808793 among children with cardiac diseases.

methodsThis case-control study included 100 pediatric cardiac patients and 50 healthy controls. GDF-15 rs4808793 (-3148C>G) single-nucleotide polymorphism was tested

resultsOf the 69 children with various types of congenital heart diseases (CHD), 14 patients had rheumatic heart disease, and 17 had cardiomyopathy. About 50% of patients had heart failure. Significantly higher mean serum GDF-15 among patients compared to the controls,

conclusionGDF-15 is a promising biomarker in predicting congenital heart disease and heart failure in children. The genetic variants of

Indexed as

Congenital heart diseasesGrowth differentiation factor 15 rs4808793Pediatric cardiologySingle nucleotide polymorphism

Identifiers

PMID42220965
PMCPMC13217203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.