ArticleWorld journal of clinical pediatrics2026
Impact of breast milk composition on nutritional status of term neonates with congenital heart defects: A prospective study.
Article in World journal of clinical pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCongenital heart defects (CHDs) are the most common congenital malformations, often requiring surgical intervention during the early neonatal period. Although most children with CHDs are born at full term with appropriate birth weights, many of them develop malnutrition during the first weeks of life, resulting in complications after cardiac surgery. This study aimed to provide new insights into personalized nutritional interventions based on variations in breast milk (BM) composition. We hypothesized that the nutritional and energy composition of BM is associated with the growth trajectory during the late neonatal period in neonates with CHDs, and it may guide individualized nutrition support.
aimTo assess the BM composition in mothers of neonates with CHD and evaluate its role in the nutritional status of these neonates.
methodsIn this single-center prospective non-interventional study, we analyzed the BM composition in 35 mothers of neonates with CHDs (25 operated, 10 non-operated) at V1 (2-5 days), V2 (7-12), and V3 (14-40), and also in 21 mothers of healthy infants at V1 (
resultsOnly the colostrum fat concentration was significantly lower in mothers of operated neonates [2.4 (2.0-2.6) g/100 mL] compared with mothers of non-operated neonates [2.9 (2.2-3.1) g/100 mL] and controls [2.7 (2.3-3.3) g/100 mL] (
conclusionColostrum from mothers of operated neonates with CHD had reduced fat content. BM composition did not affect WAZ trajectories. However, delayed achievement of full enteral feeding independently predicted WAZ decline.
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