Evidence map›Paper›PMID 42220959›Full record

ArticleWorld journal of clinical pediatrics2026

Use of nailfold capillaroscopy for evaluation of disease activity in juvenile dermatomyositis: Results of a two-center retrospective study.

Vera Podzolkova, Ilia S Avrusin, Maria Nikolaeva, Elena Afonina, Siuzanna Davtian, Asel Nurseitova, Kira Kravtsova, Aleksandra Malahova, Alexandr A Yakovlev, Sergey L Avrusin and 3 more

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Article in World journal of clinical pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Vera PodzolkovaDepartment of Children's Diseases, N.F. Filatov Clinical Institute of Children's Health, Sechenovskiy University, Moscow 119991, Moskva, Russia.
Ilia S AvrusinHospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Maria NikolaevaDepartment of Pediatric Rheumatology No. 1, Clinic of Children's Diseases, Sechenov's Center of Maternity and Childhood, Sechenovskiy University, Moscow 119991, Moskva, Russia.
Elena AfoninaDepartment of Pediatric Rheumatology No. 1, Clinic of Children's Diseases, Sechenov's Center of Maternity and Childhood, Sechenovskiy University, Moscow 119991, Moskva, Russia.
Siuzanna DavtianInternal Diseases Faculty, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenovskiy University, Moscow 119991, Moskva, Russia.
Asel NurseitovaHospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Kira KravtsovaHospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Aleksandra MalahovaHospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Alexandr A YakovlevHospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Sergey L AvrusinHospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Olga V KalashnikovaHospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Vyacheslav G ChasnykHospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Mikhail M KostikHospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia. kost-mikhail@yandex.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundJuvenile dermatomyositis (JDM) is a rare, immune-mediated children disease that affects both skeletal muscles and skin. Inflammatory vasculopathy is a key part of the JDM pathogenesis. Nailfold capillaroscopy (NFC) is a non-invasive method for microvasculature assessment. Despite the pathogenic relevance of microangiopathy in JDM, the diagnostic utility of NFC in JDM remains insufficiently defined.

aimTo quantitatively assess capillaroscopic dynamics and their association with clinical and laboratory activity markers in JDM.

methodsThis retrospective double-center cohort study included 52 children with confirmed JDM, who were followed at the clinics of Sechenov University and Saint Petersburg State Pediatric Medical University. Patients were divided into active and inactive JDM groups based on the modified disease activity score. Demographic, clinical, laboratory, and instrumental data were analyzed. NFC evaluation was performed using standardized criteria developed initially for adult patients with systemic sclerosis and Raynaud's phenomenon. Statistical analysis was conducted using Windows v.13 (StatSoft).

resultsActive and inactive JDM groups were demographically comparable (predominantly female, median onset age 6 years). NFC revealed marked differences: Active patients showed higher rates of reduced capillary density (96.2%

conclusionChildren with active JDM demonstrated more frequent NFC changes, indicating that NFC may play a potential role in monitoring disease activity. Further studies are needed to determine the diagnostic accuracy and prognostic relevance of this approach.

Indexed as

ChildrenDisease activityInflammatory myopathyJuvenile dermatomyositisNailfold capillaroscopy

Identifiers

PMID42220959
PMCPMC13217200

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