Evidence map›Paper›PMID 42220929›Full record

ArticleBasic and clinical neuroscience2025

Subthalamic Nucleus Deep Brain Stimulation in Early-onset Parkinson's Disease: Clinical Outcomes in LRRK2 Mutation Carriers Compared to Non-Carriers.

Hicham El Otmani, Mohamed Daghi, Maha Abdallaoui, Bouchra El Moutawakil, Mohammed Abdoh Rafai, Nadia Tahiri Jouti, Suzanne Lesage, Abdelhakim Lakhdar

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In one paragraph

Article in Basic and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hicham El OtmaniDepartment of Neurology, Ibn Rochd University Hospital Center, Casablanca, Morocco.ORCID https://orcid.org/0000-0003-0870-1808
Mohamed DaghiResearch Laboratory of Nervous System Diseases, Neurosensory Disorders, and Disability, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.ORCID https://orcid.org/0000-0002-9312-2239
Maha AbdallaouiDepartment of Neurology, Ibn Rochd University Hospital Center, Casablanca, Morocco.ORCID https://orcid.org/0009-0003-6791-6144
Bouchra El MoutawakilDepartment of Neurology, Ibn Rochd University Hospital Center, Casablanca, Morocco.ORCID https://orcid.org/0009-0004-1208-8449
Mohammed Abdoh RafaiDepartment of Neurology, Ibn Rochd University Hospital Center, Casablanca, Morocco.ORCID https://orcid.org/0000-0002-4342-7499
Nadia Tahiri JoutiLaboratory of Cellular and Molecular Inflammatory, Degenerative and Oncologic Pathophysiology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.ORCID https://orcid.org/0000-0002-2478-5004
Suzanne LesageInstitut du Cerveau, Institut du Cerveau, Institut National de la Santé et de la Recherche Médicale, and Centre National de la Recherche Scientifique, Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne University, Paris, France.ORCID https://orcid.org/0000-0003-4158-2601
Abdelhakim LakhdarResearch Laboratory of Nervous System Diseases, Neurosensory Disorders, and Disability, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.ORCID https://orcid.org/0000-0002-2311-4209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Subthalamic nucleus deep brain stimulation (STN-DBS) is an established treatment for early-onset Parkinson's disease (EOPD). While the effect of STN-DBS on patients with Methods: A prospective cohort study was conducted at the University Hospital of Ibn Rochd in Casablanca. Genomic DNA was analyzed for the Results: Seventeen EOPD patients who underwent STN-DBS were included, with 10(58.8%) being carriers of the Conclusion: STN-DBS is effective in managing motor symptoms and reducing medication needs in EOPD patients, regardless of

Indexed as

Deep-brain stimulationEarly-onset Parkinson’s disease (EOPD)LRRK2 mutationsSubthalamic nucleus

Identifiers

PMID42220929
PMCPMC13220684

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.