Evidence map›Paper›PMID 42220912›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Biomimetic core-shell nanofibrous scaffolds with an organic montmorillonite interlayer for tissue engineering.

Xiangrui Mao, Ruobing Cheng, Jian Zhang, Yuxiang Yao, Nan Jiang, Jinbiao Zhang, Tanlong Liu, Zhirang Hu, Yutong Liu, Zhiyong Yan and 3 more

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Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiangrui MaoCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.
Ruobing ChengAnalytical and Testing Center, Jiaxing University, Jiaxing, Zhejiang, China.
Jian ZhangCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.
Yuxiang YaoCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.
Nan JiangCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.
Jinbiao ZhangCollege of Materials Science and Engineering, Hunan University of Technology, Zhuzhou, China.
Tanlong LiuCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.
Zhirang HuCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.
Yutong LiuCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.
Zhiyong YanCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.
Chengwei YangDepartment of Orthopaedics, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, China.
Anlin YinCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.
Kuihua ZhangCollege of Materials and Textile Engineering, Jiaxing University, Jiaxing, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrospun polymer nanofibrous scaffolds have gained considerable interest in biomedical applications due to their ability to mimic the architecture and biological functions of the extracellular matrix (ECM). However, precise control over scaffold degradation is essential for ensuring predictable material behavior and supporting their intended function in tissue engineering. In this study, we develop a series of core-shell nanofibrous scaffolds composed of glycidyl methacrylate-grafted silk fibroin and poly(L-lactide-co-caprolactone) (SFMA/PLCL), incorporating an interlayer of organically modified montmorillonite (OMMT). The introduction of OMMT markedly enhances scaffold hydrophilicity, mechanical robustness, and dimensional stability, while enabling finely tunable degradation kinetics. Increasing OMMT content shifts the degradation mode from surface erosion to bulk degradation by facilitating water penetration and disrupting polymer interactions through exfoliated OMMT nanosheets and the release of quaternary ammonium ions. Moreover, the scaffolds exhibit potent antibacterial activity (>99% inhibition against Staphylococcus aureus), strong anti-biofilm performance (>75% suppression), and long-lasting antibacterial effects, all while maintaining excellent cytocompatibility. These results demonstrate that core-shell nanofibrous scaffolds with an OMMT interlayer represent a promising multifunctional platform for tissue engineering applications.

Indexed as

antibacterialcore-shell nanofiber with OMMT interlayerdegradationsilk fibrointissue engineering

Identifiers

PMID42220912
PMCPMC13215998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.