Evidence map›Paper›PMID 42220911›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Securing the U.S. nucleic acid synthesis industry: a case for safe-harbor information sharing.

Meghan J Seltzer, Alice R Isenberg, Ayanna Flegler, David W Walburger, Matthew Eric Downs, John Dileo

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meghan J SeltzerThe MITRE Corporation, McLean, VA, United States.
Alice R IsenbergThe MITRE Corporation, McLean, VA, United States.
Ayanna FleglerThe MITRE Corporation, McLean, VA, United States.
David W WalburgerThe MITRE Corporation, McLean, VA, United States.
Matthew Eric DownsThe MITRE Corporation, McLean, VA, United States.
John DileoThe MITRE Corporation, McLean, VA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The U.S. has issued guidelines for synthetic nucleic acid providers to screen order sequences and customers. However, these guidelines do not provide clear, enforceable requirements for the industry and place significant responsibility on providers to appropriately interpret and apply these guidelines. This, in turn, can lead to uneven implementation, inconsistent risk assessments, and exploitable vulnerabilities. We propose that a safe harbor information sharing network could function as a biosecurity force multiplier. Such a system would enable cross-provider analysis of order sequences and customer metadata, improve detection of suspicious activity, generate empirical evidence to refine definitions of sequences of concern and screening priorities, and provide a more robust foundation for the iterative improvement of policies, guidelines, and regulations.

Indexed as

biosecurityinformation sharing networkorder screeningsequence of concernsynthetic nucleic acid

Identifiers

PMID42220911
PMCPMC13219320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.