Evidence map›Paper›PMID 42220906›Full record

ArticleNature reviews. Materials2026

Can nanozymes achieve more than enzymes?

Shikuan Shao, Cristina-Maria Hirschbiegel, Ethan Allan, Samuel V Somerville, J Justin Gooding, Vincent M Rotello, Xiaohu Xia

Abstract read
In one paragraph

Article in Nature reviews. Materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shikuan ShaoDepartment of Chemistry, University of Central Florida, Orlando, Florida, United States.
Cristina-Maria HirschbiegelDepartment of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, United States.
Ethan AllanSchool of Chemistry and Australian Centre for NanoMedicine, University of New South Wales, Sydney, New South Wales, Australia.
Samuel V SomervilleSchool of Chemistry and Australian Centre for NanoMedicine, University of New South Wales, Sydney, New South Wales, Australia.
J Justin GoodingSchool of Chemistry and Australian Centre for NanoMedicine, University of New South Wales, Sydney, New South Wales, Australia.
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, United States.
Xiaohu XiaDepartment of Chemistry, University of Central Florida, Orlando, Florida, United States.

Funding

Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated MacrophagesR01EB022641 · NIBIB · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2017 to 2024
$3.0M
Improving ELISA Technology using Ultra-efficient Peroxidase MimicsR01EB035519 · NIBIB · UNIVERSITY OF CENTRAL FLORIDA · PI Xiaohu Xia · 2024 to 2026
$825k
NIBIB NIH HHS R01 EB022641NIBIB NIH HHS R01 EB035519NIGMS NIH HHS T32 GM139789
6 · The paper itself

Abstract

Nanozymes have progressed from simple enzyme mimics to a versatile class of artificial catalysts that expand functionality beyond the reach of natural enzymes. Their unique compositional and structural properties confer exceptional versatility in catalysis, enabling catalytic function in non-biological environments, the promotion of non-natural reactions, and the integration of multiple catalytic activities within a single nanostructure. By exploiting nanoscale control over physicochemical parameters, and/or emulating enzyme architectures, nanozymes can achieve finely tunable activity and selectivity. Their ability to undergo facile surface functionalization and provide electrical connectivity further enhances their performance in complex systems. Collectively, these attributes extend catalysis beyond the constraints of natural enzymes, driving innovations in an array of different fields including biomedicine, agriculture, environmental remediation, and energy conversion. Looking forward, rationally designed nanozymes have the potential to redefine the field of catalysis, evolving from biomimetic surrogates into transformative materials that rival, and ultimately surpass, the capabilities of natural enzymes.

Identifiers

PMID42220906
PMCPMC13221097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.