ArticleSleep advances : a journal of the Sleep Research Society2026
Sleep architecture and serum biomarker heterogeneity in obstructive sleep apnea: a cross-sectional study.
Article in Sleep advances : a journal of the Sleep Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Study Objectives: To determine whether sleep architecture is associated with heterogeneity in serum biomarkers of neuronal injury, astroglial stress, tau-related pathology, and neuroplasticity in adults with obstructive sleep apnea (OSA). Methods: Adults referred for suspected OSA underwent overnight polysomnography and next-morning fasting serum sampling. Primary analyses were restricted to participants with OSA (apnea-hypopnea index [AHI] ≥5 events/h; Results: Biomarker availability ranged from 70 to 71 participants. Lower rapid eye movement (REM) percentage was independently associated with higher ln(NSE) (beta = -0.0138 per 1 per cent REM; 95% CI = -0.026 to -0.001; Conclusions: Reduced REM sleep showed the clearest and most reproducible relationship with an adverse peripheral biomarker profile in OSA, specifically higher serum NSE. Sleep architecture may contribute to biomarker heterogeneity, but evidence for stage-dependent modification of hypoxemia-biomarker relationships remains exploratory.
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