ArticleCureus2026
A Pilot Study on the Evaluation of Hetafu Mouthwash in Oral Biofilm of Orthodontic Patients: A Clinical Trial.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Introduction Orthodontic patients are at a high risk of plaque buildup and alterations in oral microbiota due to appliance‑related retention sites. Antimicrobial mouth rinses containing bioactive components have been proposed as adjuncts to support oral microbial balance during treatment. This pilot study evaluated the effect of Hetafu mouthwash on selected beneficial and cariogenic bacteria in patients undergoing fixed orthodontic therapy. Methods A prospective clinical trial was conducted on patients undergoing orthodontic treatment at Adhiparasakthi Dental College and Hospital who met the inclusion criteria and provided informed consent. Ethical approval was obtained from the Institutional Ethical Committee of Adhiparasakthi Dental College and Hospital, Melmaruvathur (ethical approval number: ECR/1742/APDCH/ORTHO/FM 05/TN2025). The study included a total of 20 patients. The participants were instructed to use 10 mL of Hetafu mouthwash, rinsing for 30 seconds, two times daily for 240 days without altering their routine oral hygiene practices. Plaque samples were collected at the start of the study, at 60 days, and at 240 days. The samples were cultured on selective media to quantify four target organisms:
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