ArticleCureus2026
Lamotrigine and Fluoxetine Overdose Presenting With Severe Neuro-Cardiotoxicity: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lamotrigine and fluoxetine are commonly prescribed for the treatment of bipolar disorder and anxiety. Combination therapy is used in resistant bipolar depression to improve synergy and tolerability. Although most cases of lamotrigine overdose have mild toxicity, in the case of massive ingestion of more than 4 g associated with severe neurological and cardiac complications, leading to mortality, either due to severe central nervous system depression, refractory seizures, or due to cardiac arrhythmia. We describe the case of a 28‑year‑old woman with bipolar disorder who developed status epilepticus, atrial fibrillation, aspiration pneumonia, and acute kidney injury after ingesting approximately 30 tablets of lamotrigine (6000 mg) and fluoxetine (600 mg). Her recovery was further complicated by dysphagia and vocal cord dysfunction. This report highlights the importance of prompt and intensive supportive care and draws attention to the potential for uncommon cranial nerve involvement following severe mixed‑drug intoxication.
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