ArticleCureus2026
A Recently Recognized and Underdiagnosed Entity of Splenic Diffuse Red Pulp Small B-Cell Lymphoma: A Report of Two Cases.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is an extremely rare entity newly individualized in the WHO 2022 classification, following provisional recognition in 2008. It remains underrecognized in routine practice. Its diagnosis is challenging because it overlaps with other splenic lymphomas with villous lymphocytes, particularly splenic marginal zone lymphoma (SMZL) and hairy cell leukemia variants, with only a few cases reported due to recent recognition. We present two patients illustrating their distinctive diagnostic and therapeutic phenotypes. Case 1 was a 65-year-old woman diagnosed in 2017 with SMZL and treated with rituximab, cyclophosphamide, hydroxydaunorubicin (doxorubicin), oncovin (vincristine), and prednisone (or prednisolone) (R-CHOP), achieving complete remission, who presented nine years later with recurrent hyperlymphocytosis at 10.8 × 10
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