ArticleCureus2026
Immune Checkpoint Inhibitor-Induced Sarcoidosis-Like Reaction Mimicking Pulmonary Metastasis: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Immune checkpoint inhibitors can induce sarcoidosis-like reactions that mimic disease progression and pose diagnostic challenges. We report a case of a 77-year-old woman who developed pulmonary nodules during pembrolizumab therapy for recurrent uterine carcinosarcoma. Despite radiologic suspicion of metastatic disease, systemic tumor control was maintained. Thoracoscopic wedge resection revealed non-caseating granulomas without evidence of malignancy or infection, confirming a sarcoidosis-like reaction. Pembrolizumab therapy was continued without corticosteroid treatment, and the patient remained disease-free three years after treatment completion. This case highlights an important diagnostic pitfall during immune checkpoint inhibitor therapy. Sarcoidosis-like reaction should be considered in the differential diagnosis of newly developed pulmonary lesions, and histologic confirmation is essential to avoid misdiagnosis and inappropriate discontinuation of effective immunotherapy.
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