ReviewCureus2026
Elevated Systemic Inflammatory Response Index Is Associated With Increased Risk of Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute pancreatitis (AP) is a common gastrointestinal emergency with a significant proportion of patients progressing to severe acute pancreatitis (SAP), which carries substantial morbidity and mortality. A comprehensive search of the literature was performed in PubMed, Scopus, Web of Science, Embase, Cochrane Library, and Google Scholar, covering all records from database inception through February 2026. Eligible studies were those providing quantitative evidence on the association between the Systemic Inflammatory Response Index (SIRI) and the severity of acute pancreatitis (AP) in adult populations. Methodological rigor was evaluated using the Newcastle-Ottawa Scale, and statistical synthesis was conducted with a random-effects approach using RevMan software. A total of nine studies satisfied the inclusion criteria and were incorporated into the meta-analysis. The aggregated results indicated that higher SIRI values were significantly correlated with a greater likelihood of severe acute pancreatitis (odds ratio or OR: 1.99; 95% confidence interval or CI: 1.46-2.72). Furthermore, patients with severe AP exhibited markedly elevated mean SIRI levels compared with those with mild disease (mean difference or MD: 4.30; 95% CI: 0.41-8.19). Substantial heterogeneity was detected among the included studies (I² = 92% for the OR analysis and I² = 89% for the mean difference analysis). Publication bias was not assessed as the number of included studies was less than 10. The findings of this meta-analysis suggest that elevated SIRI at admission is associated with an increased risk of severe acute pancreatitis, with patients presenting with severe disease demonstrating higher SIRI values compared to those with mild pancreatitis. These results are hypothesis-generating and should be interpreted as preliminary evidence rather than definitive proof of clinical utility. Large-scale prospective studies are warranted to establish optimal cut-off values and validate their incremental utility over existing severity scores.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.