Evidence map›Paper›PMID 42220687›Full record

ArticleCureus2026

When Air Is Not an Emergency: Using Intraperitoneal Sevoflurane to Rule Out Perforation.

Riddhi Machchhar, Matthew Friedland, Tejaswi Makkapati, Eric Ball, Neil Patel, Emad Kamel, Stephen Klepner

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Riddhi MachchharInternal Medicine, Ocean University Medical Center, Hackensack Meridian Health, Brick Township, USA.
Matthew FriedlandDermatology, Yale School of Medicine, New Haven, USA.
Tejaswi MakkapatiPhysical Medicine and Rehabilitation, John F. Kennedy (JFK) University Medical Center, Hackensack Meridian Health, Edison, USA.
Eric BallInternal Medicine, Ocean University Medical Center, Hackensack Meridian Health, Brick Township, USA.
Neil PatelInternal Medicine, Ocean University Medical Center, Hackensack Meridian Health, Brick Township, USA.
Emad KamelPulmonary and Critical Care Medicine, Ocean University Medical Center, Hackensack Meridian Health, Brick Township, USA.
Stephen KlepnerGeneral Surgery, Ocean University Medical Center, Hackensack Meridian Health, Brick Township, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pneumoperitoneum (IP) is a rare diagnosis of exclusion typically discovered during imaging for unrelated concerns. Most pneumoperitoneum cases are secondary to visceral perforation, necessitating urgent surgical intervention. However, IP is a distinct, non-surgical condition that can present asymptomatically, complicating clinical decision-making. A 76-year-old female with multiple comorbidities presented to the emergency department after her Holter monitor detected intermittent, third-degree heart block. She was asymptomatic from a gastrointestinal standpoint, with a benign abdominal exam and normal inflammatory markers. However, chest imaging incidentally revealed pneumomediastinum and pneumoperitoneum, raising concern for gastrointestinal perforation. A diagnostic laparotomy was performed after temporary transvenous pacing was established. No visceral perforation was identified. Interestingly, sevoflurane administered through an endotracheal tube was detected in the abdominal cavity, suggesting a thoracoabdominal communication, possibly from a ruptured mediastinal bleb. She remained hemodynamically stable throughout hospitalization, had a permanent pacemaker placed, and was discharged in stable condition. This case highlights an unusual presentation of asymptomatic idiopathic pneumoperitoneum with suspected thoracoabdominal gas tracking, confirmed by intraoperative detection of sevoflurane. It underscores the importance of cautious interpretation of incidental pneumoperitoneum findings and the need to consider conservative management in the absence of peritonitis.

Indexed as

asymptomatic pneumomediastinumatraumaticblebidiopathic spontaneous pneumoperitoneumpulmonary blebsevoflurane

Identifiers

PMID42220687
PMCPMC13218632

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.