Evidence map›Paper›PMID 42220635›Full record

ArticleJAACAP open2026

Emotion Regulation Mediates the Link Between Exposure to Childhood Adversity and Transdiagnostic Symptom Domains in Youth.

Zhiyuan Liu, Eleni Christofilea, Gladys Alondra Venegas, Sasha Santini-Bishop, Ai Nghi Diep, Zuoheng Wang, Ilanit Gordon, James J Gross, Karim Ibrahim

Abstract read
In one paragraph

Article in JAACAP open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiyuan LiuChild Study Center, Yale University School of Medicine, New Haven, Connecticut.
Eleni ChristofileaChild Study Center, Yale University School of Medicine, New Haven, Connecticut.
Gladys Alondra VenegasChild Study Center, Yale University School of Medicine, New Haven, Connecticut.
Sasha Santini-BishopChild Study Center, Yale University School of Medicine, New Haven, Connecticut.
Ai Nghi DiepChild Study Center, Yale University School of Medicine, New Haven, Connecticut.
Zuoheng WangYale School of Public Health, New Haven, Connecticut.
Ilanit GordonBar-Ilan University, Ramat Gan, Israel.
James J GrossStanford University, Stanford, California.
Karim IbrahimChild Study Center, Yale University School of Medicine, New Haven, Connecticut.

Funding

Multimodal imaging biomarkers of cognitive control network deficits in youths with disruptive behaviorK23MH128451 · NIMH · YALE UNIVERSITY · PI Karim Ibrahim · 2022 to 2026
$959k
NIMH NIH HHS K23 MH128451NIMH NIH HHS L30 MH124229
6 · The paper itself

Abstract

Objective: Emotion dysregulation is recognized as a transdiagnostic feature common to child psychopathology. This study examined the unique association between emotion regulation difficulties and specific strategies (suppression, reappraisal) with transdiagnostic symptom domains of attention, externalizing, and internalizing problems in youth. This study also tested for the mediating role of emotion regulation between domains of childhood adversity (family conflict and negative life events) and transdiagnostic symptoms. Method: In a sample of 9,057 children aged 12 to 13 years in the Adolescent Brain Cognitive Development℠ (ABCD) Study (47.21% female), linear mixed-effects models were used to examine the association between emotion regulation difficulties and specific regulation strategies with transdiagnostic symptoms. Follow-up analyses tested replication of findings retrospectively and prospectively. Structural equation modeling was used to test whether emotion regulation mediated the association between childhood adversity (family conflict, negative life events) and symptom severity. The Child Behavior Checklist was used as a continuous measure of symptom severity. Results: Greater severity of emotion dysregulation was associated with severity of each transdiagnostic symptom domain, and these associations were replicated both retrospectively and prospectively. Sex-specific longitudinal patterns emerged for attention and externalizing problems. Emotion regulation difficulties mediated the association between childhood adversity (family conflict, negative life events) and all symptom domains, with strategy-specific patterns emerging only for internalizing problems. Conclusion: These findings have implications for developing targeted interventions to address broad emotion dysregulation as an underlying mechanism of child psychopathology linked to exposure to childhood adversity.

Indexed as

adverse childhood experiencesemotion regulationreappraisalsuppressiontransdiagnostic symptoms

Identifiers

PMID42220635
PMCPMC13221816

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.