Evidence map›Paper›PMID 42220607›Full record

ReviewMaterials today. Bio2026

A comprehensive review of mitochondrial fluorescent probes: Design principles, fluorophore engineering, and functional parameter sensing.

Fei Peng, Bo Wang, Ran Chai, Mingming Xue, Aibing Wu, Yan Lv, Huijuan Tian, Jianyuan Yu, Guigui Pang, Bin Hao and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fei PengSchool of New Materials and Chemical Engineering, Tangshan University, Tangshan, 063000, China.
Bo WangInstitute of Materials Research & Center of Double Helix, Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Ran ChaiSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan, 056000, China.
Mingming XueSchool of New Materials and Chemical Engineering, Tangshan University, Tangshan, 063000, China.
Aibing WuSchool of New Materials and Chemical Engineering, Tangshan University, Tangshan, 063000, China.
Yan LvSchool of New Materials and Chemical Engineering, Tangshan University, Tangshan, 063000, China.
Huijuan TianSchool of New Materials and Chemical Engineering, Tangshan University, Tangshan, 063000, China.
Jianyuan YuSchool of New Materials and Chemical Engineering, Tangshan University, Tangshan, 063000, China.
Guigui PangSchool of New Materials and Chemical Engineering, Tangshan University, Tangshan, 063000, China.
Bin HaoSchool of New Materials and Chemical Engineering, Tangshan University, Tangshan, 063000, China.
Baoxiang GaoSchool of Chemistry and Materials Science, Hebei University, Baoding, 071002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria are essential organelles that play pivotal roles in cellular energy metabolism, signaling, and homeostasis, and their dysfunction is closely associated with various human diseases. In recent years, the rapid development of mitochondria-targeted fluorescent probes has greatly expanded our ability to visualize mitochondrial structure and monitor diverse physicochemical and biochemical parameters in situ. While existing reviews have primarily categorized these probes by specific physiological readouts, a unified perspective that integrates probe design strategies, fluorophore engineering, and target physiological parameters is stilling lacking. To address this gap, we provide a systematic overview of mitochondrial fluorescent probes, focusing on molecular design principles, fluorophore selection, targeting strategies, and the sensing of key mitochondrial physiological indices. In addition, we critically discuss current limitations and emerging challenges, and outline future directions in this field. This review aims to offer theoretical insights and practical guidance for the rational design of mitochondrial fluorescent probes, promoting their broader applications in life science and biomedical research.

Indexed as

Design strategiesFluorescent probesMitochondriaPhysiological parameters

Identifiers

PMID42220607
PMCPMC13218268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.