Evidence map›Paper›PMID 42220606›Full record

ArticleMaterials today. Bio2026

Molecularly self-assembled nanoplatforms for targeted ROS-scavenging and neuroinflammation alleviation in acute ischemic stroke.

Xianru Bi, Meng He, Wenxuan Cao, Li Xiang, Dong Liu, Liangbo Sun, Jiqin Lian, Xia Li, Lu Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xianru BiDepartment of Clinical Biochemistry, Faculty of Pharmacy and Laboratory Medicine, Army Medical University, Chongqing, 400038, China.
Meng HeDepartment of Clinical Biochemistry, Faculty of Pharmacy and Laboratory Medicine, Army Medical University, Chongqing, 400038, China.
Wenxuan CaoDepartment of Pharmaceutical Analysis, Faculty of Pharmacy and Laboratory Medicine, Army Medical University, Chongqing, 400038, China.
Li XiangDepartment of Clinical Biochemistry, Faculty of Pharmacy and Laboratory Medicine, Army Medical University, Chongqing, 400038, China.
Dong LiuDepartment of Clinical Biochemistry, Faculty of Pharmacy and Laboratory Medicine, Army Medical University, Chongqing, 400038, China.
Liangbo SunDepartment of Clinical Biochemistry, Faculty of Pharmacy and Laboratory Medicine, Army Medical University, Chongqing, 400038, China.
Jiqin LianDepartment of Clinical Biochemistry, Faculty of Pharmacy and Laboratory Medicine, Army Medical University, Chongqing, 400038, China.
Xia LiDepartment of Pharmaceutical Analysis, Faculty of Pharmacy and Laboratory Medicine, Army Medical University, Chongqing, 400038, China.
Lu LuDepartment of Clinical Biochemistry, Faculty of Pharmacy and Laboratory Medicine, Army Medical University, Chongqing, 400038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia-reperfusion injury (CIRI) poses a pivotal barrier to neuronal survival after successful recanalization in acute ischemic stroke. This phenomenon involves multiplexed pathophysiology where oxidative stress-neuroinflammation cascades critically drive neuronal death. Although antioxidative and anti-inflammatory agents hold therapeutic promise, their clinical translation is impeded by insufficient blood-brain barrier (BBB) penetration and the challenge of simultaneously regulating multiple pathological pathways. To address these challenges, we developed a nano therapy integrating traditional Chinese and Western medicine

Indexed as

Cerebral ischemia-reperfusion injuryEastern-western fusion nanoplatformmicroglia remodelingOxidative stressSelf-assembled nanodrugs

Identifiers

PMID42220606
PMCPMC13218265

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.