Evidence map›Paper›PMID 42220566›Full record

ArticleAdvanced materials technologies2025

Tailored-Reflectivity Microstructures for Measuring Signal Sensitivity of Optical Coherence Tomography Medical Imaging Systems.

Declan M Fitzgerald, Greta Babakhanova, Christopher M Stafford, Joshua Guag, Zhuolin Liu, Daniel X Hammer, Ryan D Sochol, Anant Agrawal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials technologies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Declan M FitzgeraldCenter for Devices and Radiological Health, Food and Drug Administration Silver Spring, MD 20993, USA; Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA; Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA.
Greta BabakhanovaBiosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Christopher M StaffordMaterials Science and Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Joshua GuagCenter for Devices and Radiological Health, Food and Drug Administration Silver Spring, MD 20993, USA.
Zhuolin LiuCenter for Devices and Radiological Health, Food and Drug Administration Silver Spring, MD 20993, USA.
Daniel X HammerCenter for Devices and Radiological Health, Food and Drug Administration Silver Spring, MD 20993, USA.
Ryan D SocholDepartment of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA.
Anant AgrawalCenter for Devices and Radiological Health, Food and Drug Administration Silver Spring, MD 20993, USA.

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Optical coherence tomography (OCT) is a medical imaging technique that has transformed the practice of ophthalmology via high-resolution visualization and measurement of numerous ocular structures, the retina in particular. Despite its widespread use, the development of tools that help ensure high-quality diagnostic outcomes from OCT systems has not kept pace with the technology's rapid advancements. In this work, a novel microstructure array phantom is presented capable of directly evaluating OCT sensitivity: its ability to distinguish meaningful signal from background noise. Through a combination of two-photon direct laser writing (DLW) and thermally activated selective topographic equilibrium (TASTE), optically smooth microstructures are fabricated and shown to be effective in directly quantifying OCT sensitivity threshold, an advancement over the current practice of extrapolating system sensitivity in the high-signal regime. This phantom serves as proof-of-concept for an easily disseminated regulatory science tool that will increase the consistency of performance reporting anywhere OCT is used. The advanced fabrication techniques used in this study also serve as demonstration of what future retinal phantoms could contain, helping to close the gap between the planar, largely two-dimensional phantoms typically used for OCT systems and the geometrically complex, biomimetic phantoms common to other biomedical imaging modalities.

Indexed as

3D Printingadditive manufacturingdirect laser writingophthalmic imagingoptical coherence tomographysignal sensitivity

Identifiers

PMID42220566
PMCPMC13220254

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.