Observational studyFrontiers in immunology2026
Evaluation of oxidative stress in acute pancreatitis.
Observational study in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Editorial: Interdisciplinarity in internal medicine from basic investigations to molecular analysis.Frontiers in immunology · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oxidative stress is implicated in acute pancreatitis (AP), but its diagnos-tic/prognostic value at presentation is uncertain; this study evaluated whether redox markers discriminate radiologic severity and how they relate to inflammation and apoptosis. Methods: In this observational study cohort severity was classified as Balthazar D vs A-C score. Assays biomarkers included protein carbonyls (P-carb), lipid peroxidation state (TBARS), antioxidant status (TAC), reduced glutathione (GSH), catalase (CAT); inflammatory markers (CRP, AISI, SIRI); pro-apoptosis/innate immunity markers (caspase-3, IL-1β, AIM2). Discrimination used ROC/AUC with bootstrap CIs; a prespecified Redox Imbalance Index (RII) and exploratory load-vs-buffer ratios were derived. Correlations employed Spearman and age-adjusted partial Spearman with Benjamini Hochberg-FDR correction; logistic models used z-scored predictors with.632 bootstrap correction. Results: Single-marker discrimination was modest (GSH AUC of 0.57 [95% CI 0.24-0.85]; CRP of 0.55 [0.26-0.82]; AISI of 0.53 [0.30-0.75]); RII of 0.42 [0.17-0.69]; derived indices (POBI ≤ 0.48). Combined models overfit (apparent AUC 0.56-0.59;.632 corrected ≈0.39). By contrast, caspase-3 correlated with CRP, GSH, and P-carb (moderate, age-robust), and GSH-P-carb coupling was strong, whereas TBARS aligned weakly. Conclusions: At presentation, oxidative-stress signatures co-vary with inflammation and apoptosis (strong GSH-P-carb coupling and moderate, age-robust caspase-3 correlations with CRP and P-carb). However, neither single markers nor composite indices (including the prespecified Redox Imbalance Index) reliably discriminated radiologic severity (AUCs 0.42-0.57, all 95% CIs including 0.50). Multivariable models showed substantial overfitting after.632 bootstrap correction. These findings support further investigation of the antioxidant-protein-oxidation and apoptosis-inflammation axes in adequately powered, longitudinal studies rather than as immediate clinical triage tools.
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