SynthesisFrontiers in immunology2026
Studies on allergic diseases and B cells in the past 20 years: a bibliometric analysis via CiteSpace and VOSviewer.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research trends in cytokine regulation of immunotherapy in non-small cell lung cancer: a bibliometric and BERTopic analysis from 2015 to 2025.Journal of thoracic disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Allergic diseases represent a growing global health burden, and B cells have emerged as central yet incompletely defined regulators of IgE-mediated immunity and tolerance. There is currently a lack of bibliometric research on allergic diseases and B cells. Methods: Records were retrieved from the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) and PubMed. After applying language, time, and article-type restrictions, 3, 084 WoSCC articles and 71 PubMed-indexed clinical trials were included. CiteSpace (v6.4.R1), VOSviewer (v1.6.20), and Excel were used to analyze publication and citation trends, journals, countries, institutions, authors, keyword co-occurrence, and burst terms, and to visualize co-authorship and thematic networks. Results: Annual publications and citations increased steadily, indicating sustained academic interest. Output was concentrated in leading allergy and immunology journals and in institutions from Europe and the United States, although contributions from other regions have increased over time. Keyword clustering identified stable cores around 'food allergy, ' 'asthma, ' and 'plasma cells, ' while burst and overlay analyses highlighted 'regulatory B cells' and 'innate lymphoid cells' as emerging research hotspots. These bibliometric patterns indicate growing attention to tissue-associated B-cell biology, immune regulation, and allergen immunotherapy. PubMed clinical-trial records further suggest increasing translational interest in B-cell-related interventions for allergic diseases. Conclusions: Over the past 20 years, research on allergic diseases and B cells has evolved from descriptive immunoglobulin E (IgE) associations toward a tissue- and systems-level exploration of B-cell biology. This bibliometric analysis delineates research hotspots and translational themes, Future progress will require large, multicenter studies with standardized B-cell phenotyping and functional endpoints to support precision medicine in allergy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.