Evidence map›Paper›PMID 42220335›Full record

ArticleAdvanced functional materials2026

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration.

Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G P Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria Vittoria ColomboRegenerative Medicine Division, Institute for Translational Research, Ente Ospedaliero Cantonale - Università della Svizzera Italiana, via F Chiesa 5, Bellinzona 6500, Switzerland; Department of Chemistry, Materials and Chemical Engineering G.Natta, Politecnico di Milano, Piazzale Leonardo da Vinci 32, Milan 20100, Italy.
Chiara ArrigoniRegenerative Medicine Division, Institute for Translational Research, Ente Ospedaliero Cantonale - Università della Svizzera Italiana, via F Chiesa 5, Bellinzona 6500, Switzerland; Euler Institute, Biomedical Sciences Faculty, Università della Svizzera Italiana (USI), via Buffi 13, Lugano 6900, Switzerland.
Tobias FaehlingHopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, 69120 Heidelberg, Germany.
Antonietta VerrilloRegenerative Medicine Division, Institute for Translational Research, Ente Ospedaliero Cantonale - Università della Svizzera Italiana, via F Chiesa 5, Bellinzona 6500, Switzerland.
Viviana SecciRegenerative Medicine Division, Institute for Translational Research, Ente Ospedaliero Cantonale - Università della Svizzera Italiana, via F Chiesa 5, Bellinzona 6500, Switzerland; Department of Chemistry, Materials and Chemical Engineering G.Natta, Politecnico di Milano, Piazzale Leonardo da Vinci 32, Milan 20100, Italy; Euler Institute, Biomedical Sciences Faculty, Università della Svizzera Italiana (USI), via Buffi 13, Lugano 6900, Switzerland.
Thomas G P GrünewaldHopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, 69120 Heidelberg, Germany.
Giuseppe TalòCell and Tissue Engineering Laboratory, IRCCS Istituto Ortopedico Galeazzi, Via Cristina Belgioioso, 173, Milan 20161, Italy.
Alexandra KummerHopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, 69120 Heidelberg, Germany.
Jorge GonzalezPediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona 6500, Switzerland.
Vincenzo De RosaPediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona 6500, Switzerland.
Christian CandrianEuler Institute, Biomedical Sciences Faculty, Università della Svizzera Italiana (USI), via Buffi 13, Lugano 6900, Switzerland; Service of Orthopaedics and Traumatology, Department of Surgery, Ente Ospedaliero Cantonale, Via Tesserete 46, Lugano 6900, Switzerland.
Andrea BarberoDepartment of Biomedicine, University Hospital Basel, University of Basel, Hebelstrasse, 20, Basel 4031, Switzerland.
Florencia Cidre-AranazHopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, 69120 Heidelberg, Germany.
Matteo MorettiRegenerative Medicine Division, Institute for Translational Research, Ente Ospedaliero Cantonale - Università della Svizzera Italiana, via F Chiesa 5, Bellinzona 6500, Switzerland; Euler Institute, Biomedical Sciences Faculty, Università della Svizzera Italiana (USI), via Buffi 13, Lugano 6900, Switzerland; Cell and Tissue Engineering Laboratory, IRCCS Istituto Ortopedico Galeazzi, Via Cristina Belgioioso, 173, Milan 20161, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endochondral ossification (ECO) is the process at the basis of long bone development, occurring in children and involving vascularization and subsequent mineralization of a cartilage template. Deregulated bone developmental pathways could correlate with pediatric bone tumors, including Ewing Sarcoma (EwS), an aggressive tumor with a poor prognosis for patients with recurrent or metastatic disease. Considering the limitations of available EwS preclinical models, at developing a microphysiological system recapitulating bone developmental steps are aimed, to investigate their influence on EwS cell proliferation and migratory behavior. This system includes spheroids of mesenchymal stromal cells sequentially differentiated in chondrogenic and hypertrophic stages within a fibrin hydrogel, in the presence or not of vascular cells and mineralized particles. It shows that by modulating system components it is possible to recapitulate hypertrophic ECO stage, in a higher extent with the addition of vascular cells without a mineral component. Hypertrophic conditions foster the proliferation of EwS cells as compared to avascular and mineralized environments and support the migration of highly aggressive EWSR1::FLI1

Indexed as

endochondral ossificationewing sarcomamicrophysiological system

Identifiers

PMID42220335
PMCPMC7619114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.