Evidence map›Paper›PMID 42220313›Full record

ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

Does post-traumatic cerebral vasospasm matter?

Jody Manners, Jamie Podell, Nicolas Dorsey, Jacob Cherian, Dheeraj Gandhi, Gary Schwartzbauer, Gunjan Parikh, Neeraj Badjatia, Prajwal Ciryam

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jody MannersProgram in Trauma, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.ORCID 0000-0002-5875-3633
Jamie PodellProgram in Trauma, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.
Nicolas DorseyDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Jacob CherianDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Dheeraj GandhiDepartment of Radiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Gary SchwartzbauerProgram in Trauma, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.
Gunjan ParikhProgram in Trauma, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.
Neeraj BadjatiaProgram in Trauma, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.
Prajwal CiryamProgram in Trauma, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) encompasses heterogeneous insults and presentations resulting from blunt or penetrating mechanisms that disrupt normal cerebral function. While the primary injury may demand emergent intervention, secondary injury due to hypotension, hypoxia, edema, and ischemia can significantly worsen outcomes. Post-traumatic cerebral infarction (PTCI) remains an underrecognized but potentially preventable cause of deterioration. PTCI may arise through various systemic and brain-related factors, including those due to post-traumatic vasospasm. The clinical significance, mechanisms, and management of vasospasm after TBI are controversial and raise the question whether vasospasm is merely a marker of injury or a separate, modifiable contributor to ischemia. Thus, in this review, we examine the evidence regarding incidence, etiology, and consequence of PTCI with an emphasis on vasospasm. We highlight diagnostic challenges, therapeutic interventions, and opportunities for future clinical use directed toward improving outcomes after TBI.

Indexed as

Cerebral ischemiacerebral vasospasmpost-traumatic cerebral infarctionsecondary brain injurytraumatic brain injury

Identifiers

PMID42220313
PMCPMC13457420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.