Evidence map›Paper›PMID 42220234›Full record

ArticleHypertension (Dallas, Tex. : 1979)2026

β-Arrestin-2 Regulates Sodium Taste Processing.

Connie C Grobe, Autumn J Hamilton, Yada Treesukosol, Justin L Grobe, Jeffrey L Segar, Curt D Sigmund

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Connie C GrobeDepartment of Pediatrics (C.C.G., J.L.S.), Medical College of Wisconsin, Milwaukee, WI.
Autumn J HamiltonDepartment of Physiology (A.J.H., J.L.G., J.L.S., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.
Yada TreesukosolDepartment of Psychology, California State University Long Beach, Long Beach, CA (Y.T.).ORCID 0000-0002-2640-6813
Justin L GrobeDepartment of Pediatrics (C.C.G., J.L.S.), Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0001-9737-0873
Jeffrey L SegarDepartment of Physiology (A.J.H., J.L.G., J.L.S., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0001-7311-8948
Curt D SigmundDepartment of Physiology (A.J.H., J.L.G., J.L.S., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0002-1453-0921

Funding

Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
Intersection of the PPARγ-RhoBTB1-Cullin-3 Pathway and Renin-Angiotensin System in Blood Pressure, Vascular Function and Arterial StiffnessR35HL177123 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Curt Daniel Sigmund · 2025 to 2026
$2.2M
Impact of Early Life Sodium Intake on Growth and Metabolism – Role of Hypothalamic MechanismsR01DK133121 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI GROBE, JUSTIN L, SEGAR, JEFFREY L · 2022 to 2025
$1.9M
NHLBI NIH HHS R01 HL134850NHLBI NIH HHS R35 HL177123NIDDK NIH HHS R01 DK133121
6 · The paper itself

Abstract

backgroundAltered detection and preference for sodium are associated with increased sodium intake, and increased sodium intake is associated with increased risk of hypertension. AT

methodsSodium intake behaviors and hedonic reactions of mice carrying a null mutation of the endogenous ARRB2 gene (

results

conclusionsTogether, these findings highlight a major role for ARRB2 in sodium taste processing, which appears to be mediated through an AT

Indexed as

ArrestinsTasteTaste PerceptionAnimalsbeta-Arrestin 2beta-ArrestinsFemaleLosartanMaleMiceMice, Inbred C57BLMice, KnockoutQuinineReceptor, Angiotensin, Type 1SucroseArrb2 protein, mouseArrestinsbeta-Arrestin 2beta-ArrestinsLosartanQuinineReceptor, Angiotensin, Type 1Sucroseanimalsbrainhypertensionsodiumtaste

Identifiers

PMID42220234
PMCPMC13256247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.