Evidence map›Paper›PMID 42220051›Full record

ArticleUltrasonography (Seoul, Korea)2026

Perivascular space volume measurement at the inferior basal ganglia on cranial ultrasound in neonates: associations with germinal matrix hemorrhage and brain maturation.

Se Won Oh, Arum Choi, Dayeon Bak, Jimin Kim, Yoonho Nam, Hyun Gi Kim

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In one paragraph

Article in Ultrasonography (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Se Won OhDepartment of Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Arum ChoiDepartment of Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Dayeon BakDepartment of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea.
Jimin KimDepartment of Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yoonho NamDepartment of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea.
Hyun Gi KimDepartment of Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Funding

National Research Foundation of Korea 2021R1A2C1007831National Research Foundation of Korea RS-2023-00233871Reyon Pharmaceutical
6 · The paper itself

Abstract

purposeThe aim of this study was to assess the feasibility of cranial ultrasound (CUS)-based perivascular space (PVS) volume quantification in neonates, evaluate its relationship with magnetic resonance imaging (MRI)-based PVS volume measurements, explore associations with germinal matrix hemorrhage (GMH), and examine longitudinal changes with maturation.

methodsThis retrospective, single-center study included neonates who underwent CUS with PVS volume measurements at term-equivalent age (TEA) between November 2024 and March 2025. Neonates were grouped into those with GMH and controls. Group differences were analyzed and longitudinal changes of CUS-based PVS according to maturation were evaluated using generalized estimating equations in relation to corrected-gestational age (CGA). In neonates with both CUS and MRI at TEA, corresponding PVS volumes were compared using Spearman correlation and Bland-Altman analysis.

resultsA total of 89 neonates were included. Among 19 neonates with GMH (10 males, median [IQR], gestational age [GA]: 260 [247 to 269] days) and 70 controls (46 males, GA: 265 [254 to 274] days), those with GMH had larger CUS-based PVS volumes (0.052 [0.041 to 0.065] cm3 vs. 0.041 [0.030 to 0.054] cm3, P=0.024). Longitudinal analysis revealed increasing CUS-based PVS volume with CGA in both GMH (0.26 mm3/day, P=0.020) and control groups (0.17 mm3/day, P=0.026). CUS-based PVS volume correlated with MRI-based PVS volume (r=0.453, P=0.026) and showed good agreement on Bland-Altman analysis.

conclusionCUS-based neonatal PVS volume quantification was feasible, correlated with MRI, reflected GMH-related changes, and increased with maturation. CUS-based PVS volume quantification has the potential to serve as a valuable marker of glymphatic function in neonates.

Indexed as

Cranial ultrasoundGerminal matrix hemorrhageGlymphatic systemNeonatePerivascular spaces

Identifiers

PMID42220051
PMCPMC13246933

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