Astragalus Polysaccharides Attenuate LPS-Induced Degenerative Responses in Primary Rat Chondrocytes linked to the NLRP3/CASPASE-1 Axis.

Xiaowei Jiang, Xin Ye, Taoye Li, Zhengfeng Mei, Yichun Zhang

Abstract read

In one paragraph

Article in Journal of musculoskeletal & neuronal interactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaowei JiangDepartment of Orthopedics, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.

Xin YeDepartment of Orthopedics, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.

Taoye LiDepartment of Orthopedics, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.

Zhengfeng MeiDepartment of Orthopedics, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.

Yichun ZhangDepartment of Orthopedics, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCartilage degeneration is a key pathological change in osteoarthritis (OA). This study investigated the mechanism by which Astragalus polysaccharides (APS) alleviate cartilage degeneration.

methodsPrimary rat articular chondrocytes were isolated, and a cell degeneration model was induced with lipopolysaccharide (LPS). Different concentrations of APS (100, 200, 400 mg/L) were tested, and NLR family pyrin domain containing 3 (NLRP3)-knockdown chondrocytes were generated. Cell viability (CCK-8 metabolic activity), levels of inflammatory factors, and gene and protein levels of markers associated with cartilage degeneration (including Acan, Adamts5, Nlrp3, and Caspase-1) were measured.

resultsAPS at different concentrations improved cell viability (CCK-8) of LPS-induced chondrocytes, inhibited the inflammatory cytokines interleukin-1β (IL-1β) and IL-18, upregulated Acan, and downregulated Adamts5, Nlrp3, and Caspase-1. Nlrp3 knockdown produced similar effects to APS, improving chondrocyte degeneration in vitro.

conclusionAPS alleviates LPS-induced degenerative responses in primary rat chondrocytes, and its protective effect is associated with modulation of the NLRP3/CASPASE-1 axis.

Indexed as

Astragalus PlantCaspase 1ChondrocytesNLR Family, Pyrin Domain-Containing 3 ProteinPolysaccharidesAnimalsCells, CulturedCell SurvivalLipopolysaccharidesOsteoarthritisRatsRats, Sprague-DawleyCaspase 1LipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratPolysaccharidesArticular Cartilage DegenerationAstragalus PolysaccharidesCaspase-1NLR Family Pyrin Domain Containing 3Osteoarthritis

Identifiers

PMID42220035

PMCPMC13223790

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-SA

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.