ArticleJournal of musculoskeletal & neuronal interactions2026
Quantitative Analysis of Spontaneous Tongue Muscle Reinnervation after Long Nerve Resection for Hypoglossal Nerve Injury in Rats.
Article in Journal of musculoskeletal & neuronal interactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Neutrophil responses are substantially prolonged and robust following early postnatal chorda tympani or lingual nerve transection.Experimental brain research · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to investigate spontaneous tongue muscle reinnervation after long nerve resection for severe hypoglossal (XII) nerve injury in adult rats.
methodsThe right XII nerve was exposed, and a 9-mm section was resected. The tongue was removed and cut coronally at 4, 8, and 12 weeks after the XII nerve resection. The sections were processed for immunohistochemical staining for vesicular acetylcholine transporter (VAChT) to detect the regenerated right XII and the uninjured left XII nerve terminals. The numbers of VAChT-positive nerve terminals were counted on the injured right and uninjured left sides, and the reinnervation rate, which is the percentages of the number of VAChT-positive nerve terminals on the injured side relative to that on the uninjured side, was calculated.
resultsThe injured XII nerve gradually regenerated in the tongue after the nerve resection. The reinnervation rates in nerve-resected rats were significantly lower than those in normal rats, with mean reinnervation rates of 13.9%, 37.9%, and 41.8% at 4, 8, and 12 weeks after nerve resection, respectively.
conclusionSpontaneous reinnervation occurred in the tongue muscle after the XII nerve injury with long nerve resection and injured nerve terminals regenerated approximately 40% of the normal value; this rate was considerably lower than that with the nerve transection.
Indexed as
Identifiers
42220034PMC13223789What OpenQuestion holds
Registered trials
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