Evidence map›Paper›PMID 42220033›Full record

ArticleJournal of musculoskeletal & neuronal interactions2026

Expression of miR-27a in Patients with Steroid-associated Femoral Head Osteonecrosis and Its Regulatory Mechanism on Proliferation and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.

Zhiqing Chen, Min Wang, Zepei Zhang, Chun Zhang, Yuzhe Cao, Shaoming Liu, Shuzhang Guo, Jun Miao

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Article in Journal of musculoskeletal & neuronal interactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Zhiqing Chen *Clinical College of Orthopedics, Tianjin Medical University, China.
Min Wang *Department of Orthopedics (Spine Division), Beichen Hospital Affiliated to Nankai University, Tianjin, China.
Zepei ZhangDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, China.
Chun ZhangDepartment of Orthopedics, The Third Central Hospital of Tianjin, Tianjin, China.
Yuzhe CaoDepartment of Orthopedics, The Third Central Hospital of Tianjin, Tianjin, China.
Shaoming LiuDepartment of Orthopedics, The Third Central Hospital of Tianjin, Tianjin, China.
Shuzhang GuoDepartment of Orthopedics, The Third Central Hospital of Tianjin, Tianjin, China.
Jun MiaoDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the expression of microRNA-27a (miR-27a) in patients with steroid-associated femoral head osteonecrosis (SAN) and its regulatory effects on bone marrow mesenchymal stem cells (BMSCs).

methodsThe expression levels of miR-27a and the osteogenic-related genes Runt-related transcription factor 2 (Runx2) and bone morphogenetic protein 2 (BMP-2) were measured in bone marrow samples from SAN patients and controls. Human BMSCs were cultured

resultsThe relative expression levels of miR-27a, Runx2, and BMP-2 in bone marrow tissues of the SAN group were significantly lower than those in the control group (all P<0.001). miR-27a expression was positively correlated with Runx2 and BMP-2 expression (P<0.001). Compared with the mimic NC group, the miR-27a mimic group showed increased cell proliferation (OD values), alkaline phosphatase (ALP) activity, number of calcium nodules, and expression levels of Runx2 and BMP-2 (all P<0.05). Compared with the mimic NC group, the miR-27a inhibitor group showed significantly decreased cell proliferation (OD values), ALP activity, number of calcium nodules, and expression levels of Runx2 and BMP-2 (all P<0.05).

conclusionmiR-27a may promote the proliferation and osteogenic differentiation of BMSCs by upregulating Runx2 and BMP-2 and may represent a potential therapeutic target for the treatment of SAN.

Indexed as

Cell ProliferationFemur Head NecrosisMesenchymal Stem CellsMicroRNAsOsteogenesisAdultBone Marrow CellsBone Morphogenetic Protein 2Cell DifferentiationCells, CulturedCore Binding Factor Alpha 1 SubunitFemaleHumansMaleMiddle AgedBMP2 protein, humanBone Morphogenetic Protein 2Core Binding Factor Alpha 1 SubunitMicroRNAsMIRN27 microRNA, humanRUNX2 protein, humanassociated Femoral Head OsteonecrosisBone Marrow Mesenchymal Stem CellsCell ProliferationmiR-27aOsteogenic Differentiation

Identifiers

PMID42220033
PMCPMC13223793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.