Evidence map›Paper›PMID 42220022›Full record

ArticleJournal of musculoskeletal & neuronal interactions2026

Does a Validated Circum-menarcheal Arm Bone-Loading Index Predict Post-menarcheal Muscle Function in Adolescent Females?

Brian Josephson, Timothy Chan, Carol A Sames, Tamara A Scerpella, Jodi N Dowthwaite

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Article in Journal of musculoskeletal & neuronal interactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Brian JosephsonDepartment of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Timothy ChanDepartment of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Carol A SamesCollege of Health Professions, SUNY Upstate Medical University, Syracuse, NY, USA.
Tamara A ScerpellaDepartment of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Jodi N DowthwaiteDepartment of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn this exploratory analysis, we evaluated our validated 3-year circum-menarcheal arm bone loading index (ᴀʀᴍBLI) as a predictor of upper extremity muscle function indices in post-menarcheal females.

methodsForty-eight participants met inclusion criteria for non-dominant arm analyses, 1 to 2.5 years post-menarche: 1) menarche date (ɢʏɴAGE: yrs, menarche-centered age); 2) ᴀʀᴍBLI (3-yrs prior loading exposure); 2) grip strength (kg; primary outcome), 3) Biodex peak torques (Nm: shoulder, elbow; flexion, extension; secondary outcomes), 4) DXA arm non-bone fat-free mass (ᴀʀᴍNBꜰꜰᴍ, kg), 5) anthropometry [ulna length (mm), height (cm), weight (kg)]. Multiple linear regression evaluated muscle function in the total sample (n=48), gymnasts (n=24), and non-gymnasts (n=24), accounting for key factors: 1) whole-body model (ɢʏɴAGE, height, weight, ᴀʀᴍBLI); 2) hypertrophy model (ɢʏɴAGE, ulna length, ᴀʀᴍNBꜰꜰᴍ, ᴀʀᴍBLI).

resultsAfter accounting for key factors, ᴀʀᴍBLI was an independent negative predictor of grip strength in the total sample [hypertrophy model B= -0.202, p=0.029] and non-gymnast subsample [hypertrophy model B= -0.935, p=0.030; whole-body model B= -1.127, p=0.005]. Conversely, ᴀʀᴍBLI was an independent positive predictor of shoulder flexion peak torque in the total sample [whole-body model B= +0.270, p=0.036].

conclusionsDespite prior work showing ᴀʀᴍBLI predicts ᴀʀᴍNBꜰꜰᴍ, ᴀʀᴍBLI showed inconsistent predictive value for muscle function indices.

Indexed as

Arm BonesHand StrengthMenarcheMuscle, SkeletalAdolescentChildFemaleHumansAdolescentExerciseFemaleGrip StrengthPeak Torque

Identifiers

PMID42220022
PMCPMC13223780

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.