Evidence map›Paper›PMID 42220021›Full record

ArticlePlant biotechnology journal2026

No Cost of Resistance in Wheat Gene Stack Lines Containing 10 Stem Rust Resistance Transgenes.

Ming Luo, Aihua Wang, Soma Chakraborty, Shyh Yin Low, Saeid Babaei, Jian Chen, Jianping Zhang, Dhara Bhatt, Brenton Brooks, Oadi Matny and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ming LuoCSIRO Agriculture and Food, Canberra, Australia.
Aihua WangCSIRO Agriculture and Food, Canberra, Australia.
Soma ChakrabortyCSIRO Agriculture and Food, Canberra, Australia.
Shyh Yin LowCSIRO Agriculture and Food, Canberra, Australia.
Saeid BabaeiCSIRO Agriculture and Food, Canberra, Australia.
Jian ChenCSIRO Agriculture and Food, Canberra, Australia.
Jianping ZhangCSIRO Agriculture and Food, Canberra, Australia.ORCID https://orcid.org/0000-0003-2488-5723
Dhara BhattCSIRO Agriculture and Food, Canberra, Australia.
Brenton BrooksCSIRO Agriculture and Food, Canberra, Australia.
Oadi MatnyDepartment of Plant Pathology, University of Minnesota, St. Paul, Minnesota, USA.
Narayana UpadhyayaCSIRO Agriculture and Food, Canberra, Australia.
Rohit MagoCSIRO Agriculture and Food, Canberra, Australia.
Melania FigueroaCSIRO Agriculture and Food, Canberra, Australia.
Evans LagudahCSIRO Agriculture and Food, Canberra, Australia.
Peter DoddsCSIRO Agriculture and Food, Canberra, Australia.
Brian SteffensonDepartment of Plant Pathology, University of Minnesota, St. Paul, Minnesota, USA.ORCID https://orcid.org/0000-0001-7961-5363
Michael AyliffeCSIRO Agriculture and Food, Canberra, Australia.ORCID https://orcid.org/0000-0003-3815-7524

Funding

Gatsby Charitable FoundationLieberman-Okinow Endowment University of MinnesotaU.S. Department of Agriculture-National Institute of Food and Agriculture Hatch Project MIN-22-085
6 · The paper itself

Abstract

Genetic resistance is the most economical and sustainable approach for crop protection, however, it is regularly overcome by pathogen virulence evolution. Polygenic resistance has greater durability, but unlinked genes are laborious to maintain in breeding programs. Introducing cloned resistance genes into the genome as gene stacks enables polygenic resistance with single locus inheritance. Fielder and Robin wheat plants were generated carrying two loci that each encode five wheat stem rust resistance transgenes, that is, Sr13c/Sr21/Sr22/Sr26/Sr33 and Sr22/Sr35/Sr45/Sr50/Sr55. Multiple transgenic events were combined and tested in the field. These lines, with unprecedented levels of transgenic resistance (i.e., 10 transgenes encoded on 90 kb of sequence), showed stable gene stack inheritance and transgene expression after eight generations and were highly resistant in the field. Importantly, in the absence of disease pressure no reproducible differences in the agronomic performance of transgenic lines that contained either one or both gene stacks was seen compared with control lines over two field trial seasons. These data confirm resistance gene stack efficacy and viability as a novel durable resistance strategy in agricultural crop production. Furthermore, this isogenic material that differs only by polygenic resistance provides significant insight into the broader question of the cost of disease resistance in host plants.

Indexed as

BasidiomycotaDisease ResistancePlant DiseasesTransgenesTriticumGenes, PlantPlants, Genetically ModifiedPlant Stems

Identifiers

PMID42220021
PMCPMC13399084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.