Evidence map›Paper›PMID 42219976›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

Minute- and second-scale hippocampal network dysfunctions in the 3xTgAD mouse model of Alzheimer's disease are prevented by TSPO knockout.

Benjamin Vidal, Aurélien M Badina, Violina Dorogan, Gabriel Schirmbeck, Eduardo Sanches, Kelly Ceyzériat, Marit Knoop, Laurene Abjean, Stergios Tsartsalis, Stephane Sizonenko and 4 more

Abstract read
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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Benjamin VidalDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-0780-4215
Aurélien M BadinaDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0009-0005-1890-8986
Violina DoroganDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Gabriel SchirmbeckDivision of Child Development and Growth, Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Eduardo SanchesDivision of Child Development and Growth, Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-7783-5207
Kelly CeyzériatCIBM Center for Biomedical Imaging, Geneva, Switzerland.
Marit KnoopDivision of Child Development and Growth, Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Laurene AbjeanDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Stergios TsartsalisDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Stephane SizonenkoDivision of Child Development and Growth, Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Olivier BaudINSERM U1141, NeuroDiderot, University of Paris-Cité, Paris, France.
Philippe MilletDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Valerio ZerbiDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Benjamin B TournierDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 18 kDa translocator protein (TSPO) is widely recognized as a biomarker of neuroinflammation, but recent evidence suggests that it may also play a direct role in the pathophysiology of neurological conditions with an inflammatory component such as Alzheimer's disease (AD). In this study, we leveraged functional ultrasound imaging (fUSi) to assess how TSPO knockout influences brain activity and connectivity in the 3xTgAD mouse model of AD. Resting-state scans were performed in 16-month-old male and female mice across four genotypes: WT, TSPO

Indexed as

Alzheimer DiseaseHippocampusNerve NetReceptors, GABAAnimalsDisease Models, AnimalFemaleMaleMiceMice, KnockoutMice, TransgenicBzrp protein, mouseReceptors, GABA18 kDa translocator protein TSPOAlzheimer’s diseasefunctional ultrasound imaginghippocampusresting-state functional connectivity

Identifiers

PMID42219976
PMCPMC13420103

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.