Evidence map›Paper›PMID 42219751›Full record

ArticleBrain and behavior2026

Social and Anxiety-Like Behaviors Are Affected in Juvenile Mice With Gli2

Thomas Niepsuj, Rithika Nurani, Leykza Carreras-Simons, Wade Bushman, Joan S Jorgensen, Walid A Farhat, Anthony P Auger

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Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas NiepsujDepartment of Psychology, University of Wisconsin, Madison, Wisconsin, USA.ORCID https://orcid.org/0009-0003-3219-3505
Rithika NuraniDepartment of Psychology, University of Wisconsin, Madison, Wisconsin, USA.
Leykza Carreras-SimonsDepartment of Psychology, University of Wisconsin, Madison, Wisconsin, USA.
Wade BushmanDivision of Pediatric Urology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Joan S JorgensenDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-5787-8856
Walid A FarhatDivision of Pediatric Urology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-3298-5604
Anthony P AugerDepartment of Psychology, University of Wisconsin, Madison, Wisconsin, USA.ORCID https://orcid.org/0009-0002-9641-0348

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Department of Urology Nemours Children's HealthDepartment of Urology University of Wisconsin-MadisonNICHD NIH HHS P50 HD105353NIH HHS P51 OD011106
6 · The paper itself

Abstract

introductionGli2

aimUncover how altered GLI profiles modulate urogenital, neuroendocrine, and behavioral systems. HYPOTHESIS: Increased disruption of the GLI2/GLI3 regulatory axis will display increases in the severity of urogenital dysmorphogenesis and concurrent alterations in juvenile social and anxiety-like behaviors.

methodsMale and female mice were tested in social interaction and open field testing at postnatal days (PNDs) 24-26 and 26-29, respectively. Following behavioral testing, anogenital distance (AGD), plasma steroids: testosterone and corticosterone, and the volume of the sexually dimorphic nucleus (SDN) were taken and analyzed.

resultsSignificant differences in social and anxiety-like behaviors among genotypes were documented. Female double heterozygote Gli2

conclusionThese data suggest that morphogens that are involved in peripheral variations in sexual characteristics may also be involved in regulating anxiety-like and social development. This not only underscores the importance of mouse models in understanding genital variations and their relationship to juvenile behavior but also may be used to inform clinical approaches to those with VSCs with increased mental health concerns.

Indexed as

AnxietyBehavior, AnimalNerve Tissue ProteinsSocial BehaviorZinc Finger Protein Gli2Zinc Finger Protein Gli3AnimalsFemaleMaleMiceSex CharacteristicsTestosteroneGli2 protein, mouseGli3 protein, mouseNerve Tissue ProteinsTestosteroneZinc Finger Protein Gli2Zinc Finger Protein Gli3anxiety behaviorGLIjuvenile social behaviorvariations in sex characteristics

Identifiers

PMID42219751
PMCPMC13239559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.