ArticlePest management science2026
Design, synthesis and biological evaluation of N-phenylphthalimide derivatives as potential protoporphyrinogen IX oxidase inhibitors.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundProtoporphyrinogen IX oxidase (PPO, EC 1.3.3.4) is an important target for the development of highly efficient and environmentally friendly herbicides. Unfortunately, conventional N-phenylphthalimide-derived PPO inhibitors are often plagued by limited herbicidal spectra and unsatisfactory crop selectivity. Therefore, a series of novel and highly active broad-spectrum N-phenylphthalimide herbicidal inhibitors were designed and synthesized via the introduction of amide and isoindolinone moieties.
resultsBased on the active substructure splicing strategy, a series of N-phenylphthalimide derivatives were synthesized. Among them, compound C4 showed a strong inhibitory effect on Nicotiana tabacum PPO (NtPPO) with an inhibition constant (K
conclusionStudies have shown that the N-phenylphthalimide derivative C4, containing amide and isoindolinone structural moieties, can serve as a potential PPO inhibitor. © 2026 Society of Chemical Industry.
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