Evidence map›Paper›PMID 42219667›Full record

Trial reportJournal of digestive diseases

Multidimensional Optimization of Small Bowel Capsule Endoscopy With Transcutaneous Electrical Acustimulation: A Randomized Controlled Trial.

Yi Long Liu, Bei Fang Ning, Ya Nan Mao, Yu Hao Song, Kai Ming Wu, Xia Sheng, Kai Ding, Jiande D Z Chen, Wei Tan, Wei Fen Xie

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of digestive diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi Long LiuDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Bei Fang NingDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Ya Nan MaoDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yu Hao SongDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Kai Ming WuDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xia ShengDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Kai DingDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jiande D Z ChenDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.
Wei TanDepartment of Digestive Endoscopy, Yueyang Hospital of Integrated of Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wei Fen XieDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-7137-112X

Funding

Shanghai Municipal Health Commission 202240347Shanghai Municipal Health Commission 20244Y0160Shanghai Municipal Health Commission WF2022JC032
6 · The paper itself

Abstract

objectivesTo evaluate whether transcutaneous electrical acustimulation (TEA) during bowel preparation for small bowel capsule endoscopy (SBCE) can reduce the incidence of gastrointestinal adverse events (AEs), shorten gastric transit time (GTT), improve small bowel visualization quality, and enhance patient acceptability.

methodsWe prospectively enrolled outpatients scheduled for SBCE during December 2023 and March 2025. The participants were randomly allocated to receive either TEA at bilateral ST36 acupoints or sham stimulation (control) at non-acupoints during bowel preparation with split-dose polyethylene glycol. The primary outcome was the overall incidence of gastrointestinal AEs. Secondary outcomes included AE severity, small bowel visualization quality, GTT, and lesion detection rate, among others.

resultsA total of 39 participants completed the trial. Compared with the control group, TEA significantly reduced the overall incidence of gastrointestinal AEs during bowel preparation (p = 0.004), with particularly notable reductions in nausea and abdominal bloating. The overall severity of AEs was also markedly lower in the TEA group (p < 0.001). Furthermore, TEA significantly improved visualization quality scores for both the entire (p = 0.003) and distal small bowel (p = 0.030). GTT was significantly shorter in the TEA group (p < 0.001), and patient-reported scores for comfort (p = 0.027) and acceptability (p = 0.015) were significantly higher in the TEA group.

conclusionsTEA during SBCE bowel preparation significantly reduces gastrointestinal AEs, enhances small bowel visualization quality, and accelerates GTT. TEA is a safe and well-tolerated intervention, making it a promising adjunct to optimize SBCE.

Indexed as

Capsule EndoscopyIntestine, SmallTranscutaneous Electric Nerve StimulationAcupuncture PointsAdultAgedFemaleGastrointestinal TransitHumansMaleMiddle AgedPolyethylene GlycolsProspective StudiesPolyethylene Glycolsbowel preparationgastrointestinal motilityneuromodulationsmall bowel capsule endoscopytranscutaneous electrical acustimulation

Identifiers

PMID42219667
PMCPMC13555309

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.