Evidence map›Paper›PMID 42219615›Full record

ArticleG3 (Bethesda, Md.)2026

MKado: a toolkit for McDonald-Kreitman tests of natural selection.

Angel G Rivera-Colón, Clara T Rehmann, Andrew D Kern

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Diversity and divergence of two sympatric, sibling octopus species.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Angel G Rivera-ColónInstitute of Ecology and Evolution and Department of Biology, University of Oregon, Eugene, OR 97403, United States.
Clara T RehmannInstitute of Ecology and Evolution and Department of Biology, University of Oregon, Eugene, OR 97403, United States.ORCID 0009-0006-3475-3053
Andrew D KernInstitute of Ecology and Evolution and Department of Biology, University of Oregon, Eugene, OR 97403, United States.ORCID 0000-0003-4381-4680

Funding

Deep learning for population geneticsR01HG010774 · NHGRI · UNIVERSITY OF OREGON · PI ANDREW D KERN · 2020 to 2026
$3.2M
NHGRI NIH HHS R01 HG010774NHGRI NIH HHS R01HG010774NIH R35148253263
6 · The paper itself

Abstract

MKado is a Python toolkit for performing McDonald-Kreitman (MK) tests of natural selection from aligned coding sequences. It implements the standard MK test as well as a wide variety of its extensions and related statistics, including a number of methods for estimating the fraction of adaptive substitutions (α) while accounting for slightly deleterious mutations, with a unified command-line interface and Python API. MKado supports parallel batch processing of thousands of genes with near-linear scaling, and provides publication-ready visualizations including volcano plots and asymptotic α curves.

Indexed as

Selection, GeneticSoftwareEvolution, MolecularMutation

Identifiers

PMID42219615
PMCPMC13439947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.