Evidence map›Paper›PMID 42219575›Full record

ArticlePhysiological reports2026

Estrogen receptor β regulates sex-dependent airway mechanics and inflammation in a murine model of allergen exposure.

Carolyn Damilola Ekpruke, Dustin Rousselle, Maksat Babayev, Omar Borges-Sosa, Rachel Alford, Lyidia Dinwiddie, David Michael Merritt, Christopher Michael Hemmerich, Douglas B Rusch, Sarah Bradley and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Carolyn Damilola EkprukeDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Dustin RousselleDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Maksat BabayevDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Omar Borges-SosaDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Rachel AlfordDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Lyidia DinwiddieDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA.
David Michael MerrittCenter for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana, USA.
Christopher Michael HemmerichCenter for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana, USA.
Douglas B RuschCenter for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana, USA.
Sarah BradleyDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Matthew Louis RetznerDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Erik ParkerBiostatistics Consulting Center, Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Patricia SilveyraDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA.ORCID https://orcid.org/0000-0001-7083-8915

Funding

Sex differences in GPER-mediated mechanisms in allergic asthmaR01HL159764 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI SILVEYRA, PATRICIA · 2021 to 2024
$3.1M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL159764NHLBI NIH HHS R01 HL159764
6 · The paper itself

Abstract

Sex differences in asthma severity have been reported; however, the specific contribution of estrogen receptor β (ERβ) remains incompletely defined. We tested the hypothesis that ERβ modulates sex-specific physiological responses to chronic allergen exposure using C57BL/6J wild-type (WT) and ERβ-deficient (Esr2

Indexed as

AllergensAsthmaEstrogen Receptor betaLungRespiratory MechanicsAirway ResistanceAnimalsDisease Models, AnimalFemaleInflammationMaleMiceMice, Inbred C57BLMice, KnockoutPyroglyphidaeSex CharacteristicsAllergensEstrogen Receptor betaallergic airway inflammationasthmaestrogen receptor beta (ERβ)house dust mite (HDM)sex differences

Identifiers

PMID42219575
PMCPMC13240281

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.