Evidence map›Paper›PMID 42219481›Full record

ArticleBMC oral health2026

Clinical feasibility of high-flow nasal oxygenation during dental procedures in pediatric patients under intravenous deep sedation: initial experience.

Tong Cheng, Xiao-Ran Wu, Yun Liu, Bing-Hua Li, Xu-Dong Yang

Registry-linked trialAbstract readClinical Study
In one paragraph

Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05762692 (Clinical Feasibility and Efficacy of High-flow Nasal Oxygenation During Intravenous Deep Sedation in Pediatric Dental Patients), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05762692 naunknown statusnot on this map

Clinical Feasibility and Efficacy of High-flow Nasal Oxygenation During Intravenous Deep Sedation in Pediatric Dental Patients

TypeinterventionalSponsorPeking UniversityRan2023 to 2023Enrolled20ConditionsDeep Sedation, Dental Treatment, Pediatric PatientsArmsHigh-flow nasal oxygenation device
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tong Cheng *Department of Anesthesiology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases &  National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China.
Xiao-Ran Wu *Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases &  National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China.
Yun LiuDepartment of Anesthesiology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases &  National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China.
Bing-Hua LiDepartment of Anesthesiology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases &  National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China.
Xu-Dong YangDepartment of Anesthesiology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases &  National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China. kqyangxudong@163.com.

Funding

Clinical Research Foundation of Peking University School and Hospital of Stomatology PKUSS-2023CRF107
6 · The paper itself

Abstract

backgroundOptimal respiratory management under deep sedation remains a most concerning safety challenge for pediatric dental treatment due to its shared oral cavity. High-flow nasal oxygenation has been found to be advantageous in certain short-duration pediatric procedures and examinations. Our study aimed to further explore its clinical feasibility in preschool-aged pediatric dental treatment under deep intravenous sedation of prolonged and more complex procedures.

methodsThis study involved twenty pediatric patients scheduled for elective dental treatment with anticipated operation time of 60-120 min under deep sedation. Sedative/anesthetic agents, oxygenation management and perioperative monitoring were performed by qualified anesthesiologists. IV insertion was conducted after the child was calmed with intranasal dexmedetomidine or under general anesthesia with mask inhalation of sevoflurane. During dental treatment, oxygen administration was provided with the HFNO device with a 2.0 L/kg/min gas flow rate and an FiO

resultsAll included children successfully completed dental treatment under deep sedation. The average operation time was 74 min. None of the participants experienced any desaturation and no related complications were reported in our observation and 24 h follow-up.

conclusionsBased on our initial experience, HFNO could provide ideal oxygenation in preschool-aged pediatric dental treatment under deep sedation without clinically observed complications and adverse events. Whereas the provider qualification, strict training of HFNO device, proper use and close monitoring must be emphasized.

trial registrationThe study was registered at ClinicalTrials.gov (No. NCT05762692) and first posted on 10/03/2023.

Indexed as

Anesthesia, DentalDeep SedationDental Care for ChildrenOxygen Inhalation TherapyChildChild, PreschoolFeasibility StudiesFemaleHumansHypnotics and SedativesMaleOperative TimeOxygenPediatric AnesthesiaHypnotics and SedativesOxygenHigh-flow nasal oxygenationIntravenous deep sedationPediatric dental treatment

Identifiers

PMID42219481
PMCPMC13505133

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.