SynthesisClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Comparison of abbreviated MRI and ultrasonography in the detection of early hepatocellular carcinoma: a meta-analysis.
Synthesis in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeEarly detection of hepatocellular carcinoma (HCC) is crucial for improving clinical outcomes. Although both ultrasonography (US) and abbreviated magnetic resonance imaging (AMRI) are utilized for screening, a systematic comparison of their diagnostic performance remains lacking. This study was designed to compare the two approaches regarding their diagnostic efficacy for early-stage HCC.
methodsA systematic literature search was conducted across Web of Science, PubMed, the Cochrane Library, and Embase. Two reviewers independently screened studies and extracted data. Pooled analyses were performed using StataMP 18.0 and MetaDisc 1.4. Sensitivity, specificity, and threshold effects of AMRI and US were reported. Additionally, forest plots, funnel plots, and the pooled receiver operating characteristic (ROC) curves were generated.
resultsNine studies involving 1,914 participants were included. AMRI showed a sensitivity of 83% (95% confidence interval [CI]: 76%-88%), a specificity of 96% (95%CI: 93%-97%), and an area under the curve (AUC) of 0.91 (95% CI: 0.88-0.93). US showed a sensitivity of 47% (95% CI: 34%-61%), a specificity of 91% (95%CI: 84%-95%), and an AUC of 0.78 (95% CI: 0.74-0.82). Compared to US, AMRI demonstrated a significantly improved detection rate (risk ratio [RR] = 1.39, 95% CI: 1.16-1.67, P < 0.001). According to subgroup analyses, the findings were confounded by factors such as whether the AMRI was enhanced. No publication bias was observed.
conclusionAMRI may hold promise for the diagnosis of early-stage HCC, and its detection rate may be superior to that of US.
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