Evidence map›Paper›PMID 42219341›Full record

ArticleThe Journal of veterinary medical science2026

Systemic amyloid A amyloidosis secondary to presumed chronic vertebral osteomyelitis and pressure ulcers in a mandrill (Mandrillus sphinx).

Akiho Ishihara, Keisuke Kawase, Haruhisa Masatou, Shinya Iida, Kota Kadowaki, Hina Yamashita, Tomokazu Nagashima, Natsumi Kobayashi, Tomoaki Murakami, Honoka Kawamura and 4 more

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In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Akiho IshiharaDepartment of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.
Keisuke KawaseHitachi Kamine Zoo, Ibaraki, Japan.
Haruhisa MasatouHitachi Kamine Zoo, Ibaraki, Japan.
Shinya IidaHitachi Kamine Zoo, Ibaraki, Japan.
Kota KadowakiDepartment of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.
Hina YamashitaDepartment of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.
Tomokazu NagashimaDepartment of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.
Natsumi KobayashiLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Tomoaki MurakamiLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Honoka KawamuraDepartment of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.
Yukino MachidaDepartment of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.
Junichi KamiieLaboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Daisuke HasegawaDepartment of Veterinary Radiology, Nippon Veterinary and Life Science University, Tokyo, Japan.
Masaki MichishitaDepartment of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic amyloid A (AA) amyloidosis involves extracellular deposition of fibrils derived from serum amyloid A (SAA) and is typically associated with chronic inflammation. A 16-year-old male mandrill (Mandrillus sphinx) developed lameness and presumed chronic vertebral osteomyelitis, progressed to recumbency, and died. Histopathology revealed Congo red-positive deposits with apple-green birefringence under polarized light in multiple organs, including the liver, spleen, kidneys, heart, and intestines. Immunohistochemistry confirmed SAA immunoreactivity, and mass spectrometry identified SAA-2 as the predominant amyloid protein, establishing systemic AA amyloidosis. No infectious agents were detected in examined tissues; however, vertebral osteomyelitis and pressure ulcers were considered likely sources of persistent inflammation, which may have contributed to the development of systemic AA amyloidosis. This represents the first reported case of AA amyloidosis in a mandrill, in which amyloid A was identified and confirmed by both immunohistochemistry and mass spectrometry.

Indexed as

AmyloidosisOsteomyelitisPressure UlcerSerum Amyloid A ProteinAnimalsFatal OutcomeImmunohistochemistryMaleSerum Amyloid A Proteinimmunohistochemistrymandrillmass spectrometryserum amyloid Asystemic amyloidosis

Identifiers

PMID42219341
PMCPMC13500387

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.