Evidence map›Paper›PMID 42219309›Full record

ArticleAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2026

A Rare Case of Spontaneous Closure of Tracheomediastinal Fistula Formed after Chemotherapy for Diffuse Large B-Cell Lymphoma.

Tetsuya Kobayashi, Akie Horikiri, Nanako Yokota, Takafumi Taki, Yoshiaki Takase, Yoshihiko Kanai, Hiroyoshi Tsubochi

Abstract readCase Reports
In one paragraph

Article in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tetsuya KobayashiDepartment of General Thoracic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Akie HorikiriDepartment of General Thoracic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Nanako YokotaDepartment of General Thoracic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Takafumi TakiDepartment of General Thoracic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Yoshiaki TakaseDepartment of General Thoracic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Yoshihiko KanaiDepartment of General Thoracic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Hiroyoshi TsubochiDepartment of General Thoracic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tracheomediastinal fistula is a rare but potentially life-threatening complication associated with malignant lymphoma. We report a case of spontaneous closure of a tracheomediastinal fistula that developed after chemotherapy for mediastinal diffuse large B-cell lymphoma (DLBCL). A 70-year-old man presented with airway compression caused by a large mediastinal tumor. After airway stabilization with a Dumon Y stent and subsequent R-CHOP chemotherapy, the tumor markedly regressed. Following stent removal, a fistula developed in the anterior tracheal wall, communicating with a necrotic mediastinal space. Because no clinical or laboratory signs of mediastinitis were observed, conservative management without antibiotics or invasive intervention was adopted. The fistula gradually decreased in size and closed completely within 10 weeks. This case suggests that tracheomediastinal fistulas without mediastinitis may be managed conservatively under careful observation. Treatment strategies should be individualized based on anatomical location and the presence or absence of infection.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsLymphoma, Large B-Cell, DiffuseMediastinal DiseasesMediastinal NeoplasmsRespiratory Tract FistulaTracheal DiseasesAgedConservative TreatmentCyclophosphamideDevice RemovalDoxorubicinHumansMalePrednisoneRemission, SpontaneousRituximabCyclophosphamideDoxorubicinPrednisoneR-CHOP protocolRituximabVincristinechemotherapydiffuse large B-cell lymphomaspontaneous closuretracheomediastinal fistula

Identifiers

PMID42219309
PMCPMC13222721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.