Evidence map›Paper›PMID 42219295›Full record

ArticleBJU international2026

Pre-clinical evaluation of a laser system with emission control based on stone vs soft tissue recognition.

Olivier Traxer, Federico Zorzi, IIya V Yaroslavsky, Anastasia Kovalenko, Viktoriya Andreeva, James Childs, Alexey G Martov, Gregory Altshuler

Abstract readEvaluation Study
In one paragraph

Article in BJU international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olivier TraxerService d'Urologie, AP-HP Hôpital Tenon, Paris, France.ORCID 0000-0002-2459-3803
Federico ZorziService d'Urologie, AP-HP Hôpital Tenon, Paris, France.ORCID 0009-0000-5593-5995
IIya V YaroslavskyResearch and Development, IPG Medical, Marlborough, MA, USA.
Anastasia KovalenkoResearch and Development, IPG Medical, Marlborough, MA, USA.
Viktoriya AndreevaResearch and Development, VPG Laser One, Fryazino, Russia.
James ChildsResearch and Development, IPG Medical, Marlborough, MA, USA.
Alexey G MartovUrology Center of the Central Clinical Hospital of Civil Aviation, Moscow, Russia.
Gregory AltshulerResearch and Development, IPG Medical, Marlborough, MA, USA.

Funding

IPG photonics
6 · The paper itself

Abstract

objectiveTo evaluate the feasibility and performance of the StoneSense™ module (SSM; IPG Medical, Marlborough, MA, USA), a prototype real-time target recognition unit integrated into a IPG Thulium Fiber Laser (TFL). MATERIALS AND

methodsThe SSM analyses the spectral signature of back reflected light-emitting diode (LED) light from the target, stopping laser energy emission when incoming signal is originating from tissue or when the fibre-to-target distance is larger than pre-defined threshold (typically, ≥2-4 mm). The ex vivo tests were conducted on artificial BegoStone phantoms ((Bego GmbH & Co. KG, Bremen, Germany) embedded in porcine kidney tissue using energy settings of 0.1-2 J and 5-100 Hz at two fibre-scanning speeds (1 and 3 mm/s) through a translation stage movement. Human urinary stones were subsequently tested at 2 and 5 mm/s with setting of 0.5 J × 20 Hz. The in vivo trial was conducted by lithotripsy of pre-implanted human stones in porcine urinary tract. Primary outcome measures included ablation efficiency as well as specificity and sensitivity of stone recognition.

resultsSoft tissue ablation was completely prevented in all the ex vivo trials while maintaining high lithotripsy efficiency. Mean stone ablation reduction was 2.75% and 3% at fibre scanning speeds of 1 and 3 mm/s, respectively. The system achieved 100% sensitivity and up to 98% specificity in inhibiting laser emission to soft tissue. In vivo, complete dusting with fragments <500 μm was achieved for all studied stone types without observable mucosal injury. Specificity ranged from 85% to 100%, while sensitivity ranged from 90% to 100%.

conclusionsIntegration of back reflected-light-spectra-based laser emission control into a TFL-based lithotripsy system is feasible and effective. The SSM enables precise real-time stone recognition, minimises unnecessary lasing, and preserves dusting efficiency.

Indexed as

Kidney CalculiLithotripsy, LaserAnimalsEquipment DesignFeasibility StudiesHumansPhantoms, ImagingSwineThuliumThuliumkidney stoneslithotripsyStoneSense™Thulium Fiber Laserureteroscopy

Identifiers

PMID42219295
PMCPMC13371826

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.