Trial reportThe Journal of international medical research2026
Association of physical function and sleep with oxidative stress in adults with chronic pain: A pragmatic clinical trial secondary analysis.
Trial report in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveThis study aimed to evaluate the potential utility of 8-hydroxy-2'-deoxyguanosine as a biomarker for pain-related functional outcomes.MethodsThis is a secondary analysis of a pragmatic clinical trial that recruited active duty service members with chronic pain. Participants underwent a 6-week interdisciplinary pain management program and completed measures of sleep-related function and physical function, including objective measures of treadmill, lift, and carry battery. Urine samples were collected at baseline and 6 weeks. We estimated partial correlations among changes in 8-hydroxy-2'-deoxyguanosine, sleep-related function, and physical function, adjusting for baseline 8-hydroxy-2'-deoxyguanosine and participant demographics. Given the exploratory nature of this study, we used a significance threshold of p < 0.10.ResultsChanges in 8-hydroxy-2'-deoxyguanosine levels were negatively associated with changes in sleep-related function at both 3 weeks (r = -0.17; 90% confidence interval: -0.3 to -0.03) and 6 weeks (partial r = -0.24; 90% confidence interval: -0.38 to -0.1). Participants' sleep-related function and physical function improved from baseline to 3 and 6 weeks (
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