Evidence map›Paper›PMID 42218630›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

A Prodrug Approach for Activity-Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer's Disease.

Jimin Lee, Eunseo Hong, Chanju Na, Yan Li, Jun Go, Ju-Eun Kim, Hyun-Hee Seo, Jong-Min Suh, Jimin Kwak, Young-Ho Lee and 4 more

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jimin LeeDepartment of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Eunseo HongDepartment of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Chanju NaDepartment of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Yan LiResearch Institute of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea.
Jun GoLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
Ju-Eun KimLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
Hyun-Hee SeoLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
Jong-Min SuhDepartment of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Jimin KwakDepartment of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Young-Ho LeeCenter for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute (KBSI), Ochang, Chungbuk, Republic of Korea.
Kyoung-Shim KimLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
Chul-Ho LeeLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
Mingeun KimDepartment of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Mi Hee LimDepartment of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID https://orcid.org/0000-0003-3377-4996

Funding

KBSI C623100KBSI C623300KBSI C623500KRIBB Research Initiative Program KGM1312612NRF Grants RS-2021-NR057690NRF Grants RS-2022-NR069719NRF Grants RS-2022-NR070709NRF Grants RS-2024-00411134NRF Grants RS-2026-25508103NRF Grants RS-2026-25541458NRF Ph.D. Fellowship Grants RS-2024-00407337NRF Ph.D. Fellowship Grants RS-2025-25403620NRF Ph.D. Fellowship Grants RS-2025-25419510Sejong Science Fellowship Grant RS-2023-00214034
6 · The paper itself

Abstract

Targeting disease-specific chemical signals enables precise therapeutic control over complex pathologies. In Alzheimer's disease (AD), elevated hydrogen peroxide (H

Indexed as

Alzheimer DiseaseProdrugsAmyloid beta-PeptidesAnimalsHumansHydrogen PeroxideMiceMice, TransgenicOxidation-ReductionOxidative StressReactive Oxygen SpeciesAmyloid beta-PeptidesHydrogen PeroxideProdrugsReactive Oxygen SpeciesAlzheimer's diseasechemical modulatorsmetal‐free and metal‐bound amyloid‐β peptidesprodrugsreactive oxygen species

Identifiers

PMID42218630
PMCPMC13392803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.