Evidence map›Paper›PMID 42218537›Full record

ArticleJournal of medical case reports2026

Cherubism, emphasizing diagnosis, therapeutic management strategies, and outcomes: a case series.

Pouyan Aminishakib, Seyed MohammadMoein Hosseini, Farnoosh Mohammadi, Marjan Yaghmaie, Alireza Modarresi, Hossein Pashaiefar, Saba Sadat Tabatabaei

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In one paragraph

Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pouyan AminishakibDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Seyed MohammadMoein HosseiniSchool of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. moeinhosseini755@gmail.com.ORCID http://orcid.org/0009-0004-9971-3509
Farnoosh MohammadiDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Marjan YaghmaieHematology, Oncology & Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Alireza ModarresiDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.
Hossein PashaiefarHematology, Oncology & Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Saba Sadat TabatabaeiSchool of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Funding

Tehran University of Medical Sciences and Health Services 72077
6 · The paper itself

Abstract

backgroundCherubism is a rare fibro-osseous disorder that shows autosomal dominant inheritance, primarily caused by SH CASE PRESENTATION: Nine Persian patients (7 males, 2 females; onset 2-14 years), are reported with clinical, radiographic, histopathological, and genetic findings (in three cases) with identified mutations in two cases. Treatment strategies included observation, intra-lesional corticosteroid, surgery, denosumab, and calcitonin. Outcomes varied by modality and timing, with denosumab and calcitonin proving effective in controlling progression after surgical relapse in one case.

conclusionThis case series highlights the variable natural behavior of cherubism and provided an algorithm for diagnosis and management based on expert consensus.

Indexed as

Bone Density Conservation AgentsCalcitoninCherubismDenosumabAdaptor Proteins, Signal TransducingAdolescentAdrenal Cortex HormonesAlgorithmsChildChild, PreschoolFemaleHumansMaleMutationTreatment OutcomeAdaptor Proteins, Signal TransducingAdrenal Cortex HormonesBone Density Conservation AgentsCalcitoninDenosumabSH3BP2 protein, humanCalcitoninCase seriesCherubismDenosumabMaxillofacial surgerySH3-BP2

Identifiers

PMID42218537
PMCPMC13430865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.