ArticleScandinavian journal of trauma, resuscitation and emergency medicine2026
Transfusion and mortality after major trauma in patients on direct oral anticoagulants: a multicentre cohort study.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor trauma in patients with direct oral anticoagulants (DOACs) is increasing as treatment with DOACs is becoming more prevalent. DOACs add complexity to trauma due to increased risk of bleeding. The primary aim of this study was to compare the likelihood of packed red blood cell (PRBC) transfusion and PRBC volumes in patients with DOACs to non-anticoagulated controls after major trauma. Secondary aims were to compare mortality rates between these groups.
methodsThis was a multicentre retrospective cohort study with four participating hospitals. Inclusion criteria were age ≥ 18 years and admission for trauma with New Injury Severity Score (NISS) > 15 from Jan 1, 2019, to Dec 31, 2023. The Swedish Trauma Registry and medical records were used to identify patients and to retrieve data. For primary weighted analyses, propensity scores for DOACs were estimated using sex, age, injury mechanism, ASA class, antiplatelet treatment, and NISS. Non-weighted adjusted regression models were used for complementary analyses.
resultsA total of 1817 patients were admitted for major trauma during the study period, of which 756 patients were included in the analytic cohort. PRBC was administered to 30.8% of patients with DOACs and to 20.7% of controls. PRBC likelihood was higher among patients with DOACs (OR 1.73, 95% CI 1.03-2.91). The number of PRBC units among patients who received transfusions was not significantly higher for DOACs (GMR 1.11, 95% CI 0.79-1.56). Mortality rates within 24 h and 30 days did not differ significantly in primary analyses (OR 1.82, 95% CI 0.78-4.23 and OR 1.34, 95% CI 0.80-2.24, respectively).
conclusionsPatients with DOACs were more likely to receive PRBC transfusion, but PRBC volumes were not significantly different among transfused patients. Mortality did not differ significantly in the primary weighted analyses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.