ArticleFluids and barriers of the CNS2026
L-DOPA influences transferrin-dependent iron release at the blood-brain barrier.
Article in Fluids and barriers of the CNS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Iron dysregulation in the brain is a pathological hallmark of Parkinson's disease (PD) and contributes to oxidative stress and neurodegeneration. How the blood-brain barrier (BBB), the principal regulator of brain iron homeostasis, is implicated in this process particularly in the context of dopaminergic therapies remains unclear. In the brain interstitial space, apo-transferrin (apo-Tf), signals iron deficiency and promotes endothelial iron release, whereas holo-transferrin (holo-Tf) signals iron sufficiency and suppresses export. Here, we investigated how dopaminergic drugs modulate this transferrin-dependent regulatory system using human iPSC-derived brain endothelial cells. We quantified
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