Trial reportBMC oral health2026
Comparative assessment of four treatments for post orthodontic white spot lesions over a 24-month period: a randomized controlled clinical trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Management of white spot lesions by resin infiltration: a case series.Frontiers in oral health · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectivesThe aim of this study was to evaluate and compare the effects of resin infiltration (RI), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), fluoride varnish (FV), and fluoride toothpaste on white spot lesions (WSLs) over a 24-month period. MATERIALS AND
methodsThis study was a 24-month prospective, randomized, double-blind, multicenter clinical trial. Stratified randomization by center was employed, and patients were randomized using allocation sequences, with allocation concealment achieved via sequentially numbered, opaque, sealed envelopes. Seventy-nine participants who had finished orthodontic treatment were randomly assigned to be treated with RI, CPP-ACP, FV or fluoride toothpaste and were recalled every 6 months. The subjects in the RI group who received the RI treatment at baseline and had their teeth coated with fluoride toothpaste every six months starting from the second visit. In addition, all the participants used the provided fluoride toothpaste to brush their teeth twice daily for routine oral hygiene. The DMFT index was recorded at baseline and at each visit. Intraoral images were captured, and the changes in the WSLs area were assessed by ImageJ software.
resultsIn this study, we enrolled 20 participants in the FV group, CPP-ACP group, and RI group and 19 participants in the fluoride toothpaste group. Ultimately, 14, 17, 12, and 14 participants in each group completed the final follow-up, respectively. After 24 months, there were no significant differences in the mean DMFT index between the groups. All four treatments effectively reduced the WSLs over time. After 24 months, the rate of change in WSLs area in the RI group (-56.66 ± 20.70, 95%CI: -62.23, -51.09) was significantly lower than those in the FV group (-42.01 ± 18.12, 95%CI: -46.28, -37.75), the CPP-ACP group (-45.27 ± 18.13, 95%CI: -49.83, -40.70) and the fluoride toothpaste group (-35.19 ± 25.79, 95%CI: -40.99, -29.38). Besides, the rate of change in WSLs in the CPP-ACP group was significantly lower than that in the fluoride toothpaste group.
conclusionsDuring the 24-month period, the combined use of RI, FV, CPP-ACP with fluoride toothpaste and fluoride toothpaste alone were effective in treating WSLs. RI management achieved the best and most stable effect in terms of reducing WSLs after 24 months. In addition, after 24 months, CPP-ACP management was better than fluoride toothpaste management alone for reducing WSLs. REGISTRY: Chinese Clinical Trials Register, TRN: ChiCTR2000032516, Registration date: 1 May 2020.
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